可溶性アルギン酸ナトリウムのコレステロール, Trp-P-1及びアフラトキシンB_1のラットでの排泄に及ぼす影響

概要

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The effects of soluble sodium alginate of average molecular weight (A.M.W.), 1×10^4 (AG-1), 5×10^4 (AG-5) or 1×10^5 (AG-10) on the excretion of ^3H-labeled cholesterol, Trp-P-1 and aflatoxin B_1 in rat were compared with those of commercially available sodium alginate (A.M.W. : 2.7×10^6,AG-270) and polydextrose. In rats administered ^3H-cholesterol, the simultaneous administration of AG-10 or AG-270 (100mg/kg) significantly increased the amount of isotope excreted in feces. The administration of AG-5 or AG-10 (1000 mg/kg) after the administration of the tested compounds increased the amounts isotope excretion into feces, and decreased significantly those into urine. The administration of AG-1,however, showed no effect. These results indicate that AG-5 and AG-10 exhibited the same accelerating effects on the excretion of the tested compounds as AG-270.
社団法人日本薬学会の論文
1992-06-30