Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats
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概要
- 論文の詳細を見る
Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate on X-ray radiation-induced apoptosis was studied at 4 Gy in the colonic crypt cells of rats. Sucralfate enemas given prior to radiation resulted in the following: (1) reduction in number of apoptotic colonic crypt cells; (2) reduction in number of caspase-3 positive cells; (3) decreases in p53 accumulation and p21 expression; (4) decreases of Bax/Bcl-2 ratio. The protective effects of sucralfate against ARC may be partially due to the suppression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region.
- 日本放射線影響学会の論文
- 2006-03-31
著者
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NAKASHIMA Masahiro
Tissue and Histopathology Section, Division of Scientific Data Registry, Nagasaki University Graduat
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SHICHIJO Kazuko
Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie
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NAKAYAMA Toshiyuki
Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine
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OKUMURA Yutaka
Department of Radiation Biophysics, atomic Disease Institute, Nagasaki University School of Medicine
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Sekine I
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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Sekine Ichiro
長崎大学 医歯薬学総合研究科腫瘍診断病理学
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MATSUU-MATSUYAMA Mutsumi
Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie
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OKAICHI Kumio
Department of Radiation Biophysics, Nagasaki University Graduate School of Biomedical Sciences
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Okaichi Kumio
Department Of Radiation Biophysics Atomic Bomb Disease Institute Nagasaki University Graduate School
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Okaichi K
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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Okaichi Kumio
Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga
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Shichijo Kazuko
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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SEKINE Ichiro
Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu
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Wen Chun
Department Of Molecular Pathology
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Nakashima Masahiro
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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ISHII Kouji
Department of Anesthesiology, Nagasaki University School of Medicine
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WEN Chung
Department of Molecular Pathology
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FUKUDA Eiichiro
Department of Molecular Pathology
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Nakashima Masahiko
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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Nakashima Masahiro
長崎大医歯薬学総合研究科原研 病態分子解析
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Nakashima Masahiro
Tissue And Histopathology Section Division Of Scientific Data Registry Nagasaki University Graduate
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Nakayama Toshiyuki
Division Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Graduat
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Nakayama Toshiyuki
Department Of Hematology Kouseiren Tsurumi Hospital
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Matsuu Mutsumi
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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Shichijo Kazuko
長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 病理
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Okaichi Kumio
長崎大学医学部附属原爆後障害医療研究施設 腫瘍･診断病理学
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Sekine Ichiro
長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室
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Ishii Kouji
Department Of Anesthesiology Nagasaki University School Of Medicine
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Sekine Ichiro
Div. Of Tumor And Diagnostic Pathology Atomic Bomb Disease Inst. Nagasaki Univ. Graduate School Of B
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Sekine Ichiro
Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine
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Okumura Yutaka
Department Of Radiation Biophysics
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Nakayama Toshiyuki
Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences
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Sekine Ichiro
Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch
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Okumura Yutaka
Department Of Biostatistics Scientific Data Center For The Atomic Bomb Disaster Nagasaki University
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Shichijo Kazuko
Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute
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Okaichi Kumio
Department Of Radiation Biophysics Atomic Bomb Disease Institute
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Nagayasu Takeshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Fukuda Eiichiro
Department Of Internal Medicine Nagasaki National Medical Center
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Sekine Ichiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin
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Sekine Ichiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin
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Sekine Ichiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine
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Shichijo Kazuko
Department of Pathology Atomic Disease Institute, Nagasaki University School of Medicine
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