The Effect of Ionizing Radiation on Epidermal Langerhans Cells:A Quantitative Analysis of Autopsy Cases with Radiation Therapy

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概要

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• Langerhans cells (LCs) are dendritic cells located in the epiderm is with antigen-presenting capacities. We performed a quantitative analysis of LC density in the anterior chest skin of 286 autopsy cases, including 31 cases treated with radiation therapy. Skin specimens were stained by immunoperoxidase technique (PAP method) with an anti-S-100 protein antiserum. S-100 positive LCs were counted for comparison between nonirradiated and irradiated cases. In this study we noted that, 1) The decline in density of the LCs was age-related and dendritic processes were more prominent in younger groups. 2) The cases irradiated within one month before autopsy showed a reduction in LC density compared with age-matched controls. 3) The cases irradiated more than one month before autopsy demonstrated no consistent or definite tendency. It is suggested that ionizing irradiation as well as ultraviolet light may deplete the LC density in an acute phase. The possibility that radiation therapy alters immunological surveillance in the human skin is discussed.

• 日本放射線影響学会の論文

著者

• Matsuo Isao

  Second Department Of Internal Medicine Nagasaki University School Of Medicine

• Sekine Ichiro

  長崎大学 医歯薬学総合研究科腫瘍診断病理学

• ITO MASAHIRO

  Department of Pediatrics, School of Medicine, Mie University

• Ito Masahiro

  Department Of Pathology National Nagasaki Medical Center

• SEKINE Ichiro

  Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu

• Matsuo I

  長崎大学 医学部内科学第2

• KAWASE YOSHIHISA

  Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine

• NAITO SHlNJI

  Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine

• FUJII HIDEHARU

  Nagasaki Chuo National Hospital

• Naito Shinji

  Division Of Pathology Research Laboratory National Ureshino Hospital

• Naito Shlnji

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Fujii Hideharu

  Institute Of Genetic Resources Kyushu University

• Kawase Yoshihisa

  Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin

• Ito Masahiro

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Sekine Ichiro

  Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate School Of Biomedical Sciences

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine

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