Role of Parathyroid Hormone/Parathyroid Hormone-Related Peptide on Cell Proliferation in the Gastric Mucosa
スポンサーリンク
概要
- 論文の詳細を見る
Parathyroid hormone-related peptide (PTHrP) is widely expressed in normal tissues and elicits various functions through the PTH/PTHrP receptor. Relaxation effects of PTHrP on gastrointestinal smooth muscle cells were well documented, but the physiological role on mucosal growth and differentiation is little known. The purpose of this study was to evaluate the expression of PTHrP and PTHPTHrP receptor in the rat gastric mucosa, and the role of PTHrP on mucosal cell proliferation. Male Wistar rats were used in this study. Localization of PTHrP and PTH/PTHrP receptor were observed by immunohistochemistry and in situ hybridization. Expression of PTH/PTHrP receptor mRNA were examined by RNase protection assay in control and stress condition. Double staining with BrDU incorporation was performed to differentiate cell cycle states. Cell proliferative effect by external PTHrP-(1-34) was evaluated by BrDU incorporation. PTHrP immunopositive cells were encountered in and around the mucosal neck area. PTH/PTHrP receptor immunoreactivity was observed in the gastric mucosa broadly. Cells with stronger expression for PTHrP and its cognate receptor were located in the vicinity of generative zone. But BrDU incorporating cells were negative for both PTHrP and PTH/PTHrP receptor. By RNase protection assay, PTH/PTHrP receptor mRNA expression was weak in a steady state, and the receptor expression increased at stress. External PTHrP-(1-34) did not show cell proliferative effect in a steady state. At stress BrDU incorporation was suppressed significantly, and PTHrP-(1-34) increased BrDU incorporation. These observations suggest that PTHrP and PTH/PTHrP receptor involve maintenance of mucosal growth and differentiation in the stomach.
- 長崎大学の論文
著者
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Nagayasu Takeshi
長崎大学 大学院腫瘍外科
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Matsuo Isao
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Ito M
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Sekine I
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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Sekine Ichiro
長崎大学 医歯薬学総合研究科腫瘍診断病理学
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Matsuo Isao
The Second Department Of Internal Medicine Nagasaki University School Of Medicine
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ITO MASAHIRO
Department of Pediatrics, School of Medicine, Mie University
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Mori Iwao
Department Of Internal Medicine Nagasaki Municipal Hospital
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Ito Masahiro
Department Of Pathology National Nagasaki Medical Center
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Shichijo Kazuko
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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Matsuo Isao
長崎大学 医学部内科学第2
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SHIKUWA SABURO
Department of Internal Medicine, Nagasaki Chuo National Hospital
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Matsuo I
長崎大学 医学部内科学第2
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Nakashima Masahiko
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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Nakashima Masahiro
長崎大医歯薬学総合研究科原研 病態分子解析
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Nakashima Masahiro
Tissue And Histopathology Section Division Of Scientific Data Registry Nagasaki University Graduate
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Nakayama Toshiyuki
Division Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Graduat
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Matsuu Mutsumi
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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Shichijo Kazuko
長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 病理
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Sekine Ichiro
長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室
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Ito Masahiro
国立病院長崎医療センター
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Sekine Ichiro
Div. Of Tumor And Diagnostic Pathology Atomic Bomb Disease Inst. Nagasaki Univ. Graduate School Of B
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Sekine Ichiro
Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine
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Shikuwa Saburo
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Shikuwa Saburo
Department Of Gastroenterology National Nagasaki Medical Center
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Shikuwa Saburo
Department Of Pathology And Second Department Of Internal Medicine Nagawaki Universtiy School Of Med
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Nakayama Toshiyuki
Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences
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Sekine Ichiro
Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch
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Ito Masahiro
Department Of Gastroenterological Surgery Fujita Health University
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Ito Masahiro
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Ito Masahiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici
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Sekine Ichiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin
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Ito Masahiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine
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