The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the effect of fermented milk kefir on X-ray-induced apoptosis in the colon of rats, we examined the apoptotic index, the mean number of apoptotic cells detected by H&E staining per crypt in the colon, in control rats and kefir-pretreated rats drinking kefir for 12 days before irradiation. Apoptotic cells were confirmed by TUNEL staining, and active caspase-3 expression was studied by immunohistochemistry. The cell position of apoptotic cells and active caspase-3 positive cells were examined. The apoptotic index of kefirtreated rats was significantly (p < 0.05) decreased 2 h after 1 Gy irradiation in comparison with control rats at crypt cell positions 1-3, 5-7, 13, and 15. Active caspase-3 expression in the kefir-treated rats was also significantly (p < 0.05) reduced in comparison with control rats 2 h after 1 Gy irradiation at crypt cell positions 1-4, 13, and 15. This study indicated that kefir protects colonic crypt cells against radiation-induced apoptosis, which was most pronounced in the stem cell region of the crypt. The antiapoptotic effect of fermented milk kefir was due to the inhibition of caspase-3 activation.
- 日本放射線影響学会の論文
著者
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NAKASHIMA Masahiro
Tissue and Histopathology Section, Division of Scientific Data Registry, Nagasaki University Graduat
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SHICHIJO Kazuko
Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie
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Nagayasu Takeshi
長崎大学 大学院腫瘍外科
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NAKAYAMA Toshiyuki
Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine
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Sekine I
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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Sekine Ichiro
長崎大学 医歯薬学総合研究科腫瘍診断病理学
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OKAICHI Kumio
Department of Radiation Biophysics, Nagasaki University Graduate School of Biomedical Sciences
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Okaichi Kumio
Department Of Radiation Biophysics Atomic Bomb Disease Institute Nagasaki University Graduate School
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Okaichi K
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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Okaichi Kumio
Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga
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Shichijo Kazuko
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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MATSUU Mutsumi
Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu
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SEKINE Ichiro
Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu
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Wen Chun
Department Of Molecular Pathology
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Nakashima Masahiro
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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FUKUDA Eiichiro
Department of Molecular Pathology
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SHIRAHATA SANETAKA
Laboratory of Cellular Reguration Technology, Graduate School of Genetic Resourses Technology, Kyusy
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TOKUMARU SENNOSUKE
Nihon Kefir Co. Ltd.
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Nakashima Masahiko
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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Nakashima Masahiro
長崎大医歯薬学総合研究科原研 病態分子解析
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Nakashima Masahiro
Tissue And Histopathology Section Division Of Scientific Data Registry Nagasaki University Graduate
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Nakayama Toshiyuki
Division Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Graduat
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Nakayama Toshiyuki
Department Of Hematology Kouseiren Tsurumi Hospital
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Matsuu Mutsumi
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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Shichijo Kazuko
長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 病理
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Okaichi Kumio
長崎大学医学部附属原爆後障害医療研究施設 腫瘍･診断病理学
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Sekine Ichiro
長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室
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Sekine Ichiro
Div. Of Tumor And Diagnostic Pathology Atomic Bomb Disease Inst. Nagasaki Univ. Graduate School Of B
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Sekine Ichiro
Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine
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Shirahata S
Fac. Of Agriculture Kyushu Univ.
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Nakayama Toshiyuki
Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences
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Sekine Ichiro
Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch
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Shichijo Kazuko
Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute
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Okaichi Kumio
Department Of Radiation Biophysics Atomic Bomb Disease Institute
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Fukuda Eiichiro
Department Of Internal Medicine Nagasaki National Medical Center
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Sekine Ichiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin
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Sekine Ichiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin
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Sekine Ichiro
Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine
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Shichijo Kazuko
Department of Pathology Atomic Disease Institute, Nagasaki University School of Medicine
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