Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells

スポンサーリンク

概要

• 論文の詳細を見る

• We previously reported that the apoptosis index in jejunal crypt cells after X irradiation was greater in spontaneously hypertensive rats than in Wistar-Kyoto rats. Moreover, these same cells showed a suppression of apoptosis when reserpine was administered to induce sympathetic dysfunction in spontaneously hypertensive rats or Wistar-Kyoto rats.1) Whether the hyperfunction of the sympathetic nervous system is involved in the high susceptibility of the jejunal crypt cells to radiation-induced apoptosis was the subject of this study. The effect of norepinephrine (NE) on cell survival was examined using the colony formation assay after X-ray irradiation of rat ileal epithelial cells (IEC-18). The addition of 1 μM NE decreased the surviving fraction of cells irradiated with 6 Gy from 37% to 8%. The radiosensitivity of IEC-18 cells was enhanced by the addition of 1 μM of NE. The irradiation and treatment with NE also resulted in an increased cellular apoptotic rate. These results showing enhanced radiosensitivity of rat ileal epithelial cells by NE suggest that NE may be one of the factors which aggravate acute radiation injury in the intestine.

著者

• SHICHIJO Kazuko

  Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie

• NAKAYAMA Toshiyuki

  Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine

• MATSUU-MATSUYAMA Mutsumi

  Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie

• OKAICHI Kumio

  Department of Radiation Biophysics, Nagasaki University Graduate School of Biomedical Sciences

• NAKASHIMA Masahiro

  Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie

• SEKINE Ichiro

  Nagasaki Red Cross Blood Center

• Okaichi K

  Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn

• Okaichi Kumio

  長崎大学医学部附属原爆後障害医療研究施設 腫瘍･診断病理学

関連論文

• Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability.
• Constraints on the Time Variation of the Fine Structure Constant by the 5-Year WMAP Data(Astrophysics and Cosmology)
• Malignant lymphoma of the stomach after chemotherapy for hepatocellular carcinoma
• Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells
• Establishment of Telemedicine System for International Hibakushas' Medical Care
• Expansion of identical B-cell clones in the bilateral parotid glands and their circulation in the peripheral blood in a patient with Sjogren's syndrome
• Panniculitis in a patient with mixed connective tissue disease
• Sensitivity to Ionizing Radiation in Saos-2 Cells Transfected with Mutant p53 Genes Depends on the Mutation Position
• Mutation-points of p53 affect the sensitivity of the cell to anticancer drugs.
• The sensitivity to ionizing radiation and radiation-induced apoptosis in Saos-2 cells transfected by four mutants and wild typc p53.
• How will a mutation of p53 affect the sensitivity of the cell to ionizing radiation.
• Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis
• Cell growth and morphology of Dictyostelium discoideum in space environment
• Cell growth and morphology of Dictyostelium discoideum in space environment
• Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells
• Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats
• Immunohistochemical examination of mucinous cystadenoma of the testis
• The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats
• Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing
• The protective effect of a fermented milk Kefir to radiation-induced apoptosis in rat colon
• Two Cases of Multiple Carcinoid Tumors and Gastric Enterochromaffin-like Cell Hyperplasia, Dysplasia and Neoplasia in Type A Gastritis
• Involvement of Wnt Pathway during Colonic Carcinogenesis Induced by Irradiation
• The Protective Effect of Interleukin-11 on the Cell Death Induced by X-ray Irradiation in Cultured Intestinal Epithelial Cell
• The suppression effect of sucralfate and soduim butyrate on radiation-induced apoptosis
• Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression
• Establishment and Characterization of a Malignant Epithelioid Hemangioendothelioma from Mouse Thyroid Tumor
• Heat sensitivity of DNA-dependent protein kinase activity
• Response to Cyclosporine Therapy in Patients with Myelodysplastic Syndrome : A Clinical Study of 12 Cases and Literature Review
• The Role of the Sympathetic Nervous System in Radiation-induced Apoptosis in Jejunal Crypt Cells of Spontaneously Hypertensive Rats
• Acute Irradiation Injury and Autonomic Nervous System
• Autopsy case of colocalized tumors of hepatocellular carcinoma and malignant lymphoma
• The phosphatidylinositol 3-kinase, inhibited by low dose of wortmannin, affects radiation sensitivity
• RBE for scid cells irradiated with high LET radiations
• Expression of ICAM-1 and Acute Inflammatory Cell Infiltration in the Early Phase of Radiation Colitis in Rats
• A mutant human p53, 123A, which led to apoptosis but not Waf-1 in response to ionizing radiation in a human osteosarcoma cell line, Saos-2
• A Solitary Bronchial Papilloma with Malignant Changes
• JET FLOW ISSUING FROM CIRCULAR PIPE WITH FLUTTERING FINS(Special Nozzle)
• Hypergravity Induces Phosphorylation of p53 at Serine 15, but not an Expression of p53-downstream Genes
• 128 Analysis of gene expression induced by hypergravity using DNA chip(Effects of space radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Accumulation and phosphorylation of p53 by hypergravity
• Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53
• Cross talk of p53 signal pathway by low dose radiation and artificial gravity
• Phosphorylation of p53 by low dose X-ray irradiation
• Recovery of heat inactivated DNA-PK activity and HSC73
• Recovery of heat inactivated DNA-PK activity and repair of DNA double strand break
• Sensitivity of Heavy-Ion Beam in Scid Mouse Lung Fibroblast Cells.
• Thermosensitivity and DNA-PK activity of scid cells and hybrid scid cells containing human chromosome 8
• Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells

もっと見る 閉じる

スポンサーリンク