The Protective Effect of Interleukin-11 on the Cell Death Induced by X-ray Irradiation in Cultured Intestinal Epithelial Cell

スポンサーリンク

概要

• 論文の詳細を見る

• Interleukin-11/PI3K/X-ray Irradiation/Intestinal Epithelial Cell. Interleukin-11 (IL-11) is a well known anti-inflammatory cytokine that is associated with cell growth, and also participates in limiting X-ray irradiation induced intestinal mucosal injury. The aim of this study was to evaluate the protective effect of IL-11 on the cell injury induced by X-ray irradiation in rat intestinal epithelial IEC-18 cells. Recombinant human IL-11 (rhIL-11) treated cells were irradiated and then examined for cell viability. To evaluate irradiation injury, trypan blue staining was used to detect the dead cells. The viability of irradiated cells was up-regulated by rhIL-11 treatment and also resulted in the activation of p90 ribosomal S6 kinase (p90RSK) and S6 ribosomal protein (S6Rp). Wortmannin, a specific inhibitor of PI3K, suppressed the activation of S6Rp in rhIL-11 treated cells, and decreased the up-regulation of viability by rhIL-11 treatment in irradiated cells. The TUNEL assay was also perfomed to estimate the rate of apoptosis in X-ray induced cell death. There was no difference in the results between trypan blue staining and the TUNEL assay. Further, rhIL-11 down-regulated the expression of cleaved caspase-3 in irradiated cells. These results suggest that rhIL-11 may play an important role in protection from radiation injury.

• 日本放射線影響学会の論文
• 2007-03-20

著者

• SHICHIJO Kazuko

  Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie

• Uemura Takashi

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• NAKAYAMA Toshiyuki

  Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine

• Sekine I

  Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute

• Sekine Ichiro

  長崎大学 医歯薬学総合研究科腫瘍診断病理学

• YAKATA Yuichi

  Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer

• MATSUU-MATSUYAMA Mutsumi

  Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie

• Shichijo Kazuko

  Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien

• SEKINE Ichiro

  Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu

• Yakata Yuichi

  Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Gradu

• Yakata Yuichi

  Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi

• UEMURA Takashi

  Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center

• KUSABA Takafumi

  Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Gra

• YAMAZUMI Kazuyuki

  Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Gra

• Nakayama Toshiyuki

  Division Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Graduat

• Nakayama Toshiyuki

  Department Of Hematology Kouseiren Tsurumi Hospital

• Matsuu Mutsumi

  Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien

• Uemura Takashi

  Clinical Research Center National Hospital Organization (nho) Nagasaki Medical Center

• Shichijo Kazuko

  長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 病理

• Uemura Takashi

  Department Of Applied Biological Science Science University Of Tokyo

• Sekine Ichiro

  長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室

• Sekine Ichiro

  Div. Of Tumor And Diagnostic Pathology Atomic Bomb Disease Inst. Nagasaki Univ. Graduate School Of B

• Sekine Ichiro

  Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine

• Nakayama Toshiyuki

  Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences

• Sekine Ichiro

  Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch

• Shichijo Kazuko

  Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute

• Nagayasu Takeshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yamazumi Kazuyuki

  Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Gradu

• Kusaba Takafumi

  Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Gradu

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine

• Shichijo Kazuko

  Department of Pathology Atomic Disease Institute, Nagasaki University School of Medicine

関連論文

• Radiofrequency Energy Induced Ventricular Fibrillation in a Case of Idiopathic Premature Ventricular Contraction Originating from the Left Ventricular Papillary Muscle
• Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability.
• PJ-709 Analysis of the Effective Regimen which Reduces the Incidence of Atrial Fibrillation in Metabolic Syndrome(PJ119,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 7 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• PJ-572 Oxidative Stress Expressed by the Urinary Level of 8-Hydroxy-2'-Deoxyguanosine and Biopyrrin Decreases after Cardioversion in Atrial Fibrillation(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annual Sc
• PJ-281 Analysis of the Relation between the Urinary Microalbumin Excretion and the Prevalence of Atrial Fibrillation(PJ047,Arrhythmia, Others (Clinical/Pathophysiology) 3 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Cir
• PJ-157 Analysis of the Change of Von Willebrand Factor and ADAMTS13 Concentration following Radiofrequency Catheter Ablation of Atrial Fibrillation(PJ027,Arrhythmia, Others (Clinical/Pathophysiology) 2 (A),Poster Session (Japanese),The 73rd Annual Scienti
• PJ-008 Analysis of the Mechanisms Responsible for Genesis of Complex Fractionated Atrial Electrograms during Atrial Fibrillation Using 3D Non-contact Mapping System(PJ002,Atrial/Supraventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Ja
• PE-483 Radial Augmentation Index : An Useful Marker in Predicting the Occurrence of Paroxysmal Atrial Fibrillation in Hypertensive Men(PE081,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (English),The 73rd Annual Scientific Meetin
• PE-162 Improvement Effect on the Endothelial Function in Patients with Congestive Heart Failure Treated by Cardiac Resynchronization Therapy(PE027,CRT (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-709 Analysis of the Effective Regimen which Reduces the Incidence of Atrial Fibrillation in Metabolic Syndrome(PJ119,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 7 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• PJ-572 Oxidative Stress Expressed by the Urinary Level of 8-Hydroxy-2'-Deoxyguanosine and Biopyrrin Decreases after Cardioversion in Atrial Fibrillation(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annual Sc
• PJ-281 Analysis of the Relation between the Urinary Microalbumin Excretion and the Prevalence of Atrial Fibrillation(PJ047,Arrhythmia, Others (Clinical/Pathophysiology) 3 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Cir
• PJ-157 Analysis of the Change of Von Willebrand Factor and ADAMTS13 Concentration following Radiofrequency Catheter Ablation of Atrial Fibrillation(PJ027,Arrhythmia, Others (Clinical/Pathophysiology) 2 (A),Poster Session (Japanese),The 73rd Annual Scienti
• PJ-008 Analysis of the Mechanisms Responsible for Genesis of Complex Fractionated Atrial Electrograms during Atrial Fibrillation Using 3D Non-contact Mapping System(PJ002,Atrial/Supraventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Ja
• PE-483 Radial Augmentation Index : An Useful Marker in Predicting the Occurrence of Paroxysmal Atrial Fibrillation in Hypertensive Men(PE081,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (English),The 73rd Annual Scientific Meetin
• PJ-593 Effect of Nifekalant on the Right Atrial Electrophysiologic Characteristics During Typical Atrial Flutter(Arrhythmia, diagnosis/Pathophysiology/EPS(15)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
• PJ-588 Plasma Von Willebrand Factor and ADAMTS13 Concentrations in Atrial Fibrillation(Arrhythmia, diagnosis/Pathophysiology/EPS(10)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-239 Mechanisms of the Maintenance of Atrial Fibrillation : Role of the Complex Fractionated Atrial Electrograms Region Assessed by Non-contact Mapping(Arrhythmia, diagnosis / Pathophysiology / EPS(04)(A),Oral Presentation (Japanese),The 72nd Annual Sci
• OJ-235 Effect of Linear Left Atrial Roof Line Ablation on the Extent and Location of the Complex Fractionated Atrial Electrogram (CFAE)(Arrhythmia, diagnosis / Pathophysiology / EPS(04)(A),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of
• Malignant lymphoma of the stomach after chemotherapy for hepatocellular carcinoma
• Catheter Ablation of a Polymorphic Ventricular Tachycardia Inducing Monofocal Premature Ventricular Complex
• Successful Treatment With a Chimeric Anti-CD20 Monoclonal Antibody (IDEC-C2B8, Rituximab) for a Patient With Relapsed Mantle Cell Lymphoma Who Developed a Human Anti-Chimeric Antibody
• Recovery of Hematopoietic Progenitor Cells in Patients With Severe Aplastic Anemia Who Obtained Good Clinical Response With a Combination Therapy of Immunosuppressive Agents and Recombinant Human Granulocyte Colony-Stimulating Factor
• Compositional Phase Separation in La_Ba_xCuO_y near the Optimum Composition for Superconductivity
• Meissner Effect in La_Ba_xCuO_y as Functions of x and y
• ^Cu NMR Study of Spin Dynamics in La_(Sr,Ba)_xCuO_y(0.04≦x≦0.16,3.99≦y≦4.03)
• Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells
• Correlation between Angiogenesis and p53 Expression in Lung Adenocarcinoma of Young Patients
• Ets-1 Proto-Oncogene as a Potential Predictor for Poor Prognosis of Lung Adenocarcinoma
• Expression and Significance of Angiopoietin-1, 2 and Tie-2 Receptor in Human Extrahepatic Bile Duct Carcinoma: Correlation with Clinicopathological Factors
• Establishment of Telemedicine System for International Hibakushas' Medical Care
• Amphiphilic Tetrathiafulvalene Derivative : Charge-Transfer Complexation Behavior in Solutions
• Intramolecular Charge-Transfer Polymers between Dithiafulvene and Pyridinium Units : Conjugative Effect through Saturated Polymethylene Chains
• Self-Complexation of a Poly-Conjugated Donor Molecule with a Cyclic Acceptor
• Linearly Extended π-Conjugated Dithiafulvene Polymer Formed Soluble Charge-Transfer Complex with 7,7,8,8-Tetracyanoquinodimethane
• Expansion of identical B-cell clones in the bilateral parotid glands and their circulation in the peripheral blood in a patient with Sjogren's syndrome
• Expression of Superoxide Dismutase in Basal Cell Carcinoma
• Incidence of multiple primary cancers in Nagasaki atomic bomb survivors: association with radiation exposure.
• Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis
• 40 Cyclin D1 Overexpression in Thyroid Tumors from the Radio-contaminated Area, and its Correlation with Pin1 and Aberrant beta-Catenin Expressions(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Incidence and Mechanism of Dislocated Fast Pathway in Various Forms of Atrioventricular Nodal Reentrant Tachycardia
• PJ-194 Urinary 8-Hydroxy-2'-Deoxyguanosine Levels Decrease after Electrical Cardioversion in Atrial Fibrillation(Arrhythmia, diagnosis/pathophysiology/EPS-11, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-489 Metabolic Syndrome is the Important Risk Factor for Atrial Fibrillation(Diabetes/Obesity/Metabolic syndrome-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-612 Analysis of the Post Pacing Interval after Entrainment between Patients with Channel Dependent and Channel Independent Macroreentrant Atrial Tachycardias(Arrhythmia, diagnosis/pathophysiology/EPS-14 (A) PJ103,Poster Session (Japanese),The 70th Anni
• PJ-463 Analysis of the Effect of Angiotensin-converting Enzyme Inhibitor and Angiotensin Receptor Blocker in Preventing the Reccurrence of Atrial Fibrillation(Arrhythmia, therapy-16 (A) PJ78,Poster Session (Japanese),The 70th Anniversary Annual Scientific
• PE-220 Anatomical and Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia Accompanied by the Block in the Upper Common Pathway(Arrhythmia, diagnosis/pathophysiology/EPS-9 (A) PE37,Poster Session (English),The 70th Annivers
• OE-277 Analysis of the Anatomical Tachycardia Circuit in Verapamil-sensitive Atrial Reentrant Tachycardia Originating From the Vicinity of the Atrioventricular Node(Arrhythmia, diagnosis/pathophysiology/EPS-2 (A) OE47,Oral Presentation (English),The 70th
• OE-172 Differentiation of Atrioventricular Nodal Reentrant Tachycardia with Lower Common Pathway Block From Atrial Reentrant Tachycardia Originating From Atrioventricular Node Vicinity(Arrhythmia, diagnosis/pathophysiology/EPS-1 (A) OE29,Oral Presentation
• Expression of Wnt Signaling Pathway in Thyroid Cancers from Residents living around Semipalatinsk NuclearTest Site
• Acinar cell carcinoma of the pancreas associated with hypoglycemia: Involvement of "big" insulin-like growth factor-II
• Cleaning Efficacy of Different Irrigation in Root Canal Treatment
• Molecular Pathology of Radiation-Induced Thyroid Cancer
• Childhood Thyroid Cancer:Comparison of Japan and Belarus
• Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells
• Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats
• Immunohistochemical examination of mucinous cystadenoma of the testis
• The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats
• Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing
• The protective effect of a fermented milk Kefir to radiation-induced apoptosis in rat colon
• Cyclin D1 overexpression in Thyroid Tumors in the Radio-contaminated area after the Chernobyl accident, and its Relations with Aberrant betacatenin and Pin1 expression
• Two Cases of Multiple Carcinoid Tumors and Gastric Enterochromaffin-like Cell Hyperplasia, Dysplasia and Neoplasia in Type A Gastritis
• Cellular Neurothekeoma A with an Immunohistochemical Study
• Role of Parathyroid Hormone/Parathyroid Hormone-Related Peptide on Cell Proliferation in the Gastric Mucosa
• Involvement of Wnt Pathway during Colonic Carcinogenesis Induced by Irradiation
• Incidence of Intracranial Meningiomas in Nagasaki Atomic Bomb Survivors
• The Protective Effect of Interleukin-11 on the Cell Death Induced by X-ray Irradiation in Cultured Intestinal Epithelial Cell
• Autocrine/Paracrine Involvement of Parathyroid Hormone-Related Peptide in Vascular Leiomyoma
• The suppression effect of sucralfate and soduim butyrate on radiation-induced apoptosis
• The sympathetic nervous system promotes carbon tetrachloride-induced liver cirrhosis in rats by suppressing apoptosis and enhancing the growth kinetics of regenerating hepatocytes
• Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression
• Histopatbological findings of childhood thyroid cancer in Gome, Belarus
• Usefulness of thyroid ultrasound and fine needle aspiration cytology to evaluate the incidence of thyroid diseases in children around Chemobyl
• Radical Copolymerizations of Vinyl Monomers in a Porous Coordination Polymer
• Response to Cyclosporine Therapy in Patients with Myelodysplastic Syndrome : A Clinical Study of 12 Cases and Literature Review
• The Role of the Sympathetic Nervous System in Radiation-induced Apoptosis in Jejunal Crypt Cells of Spontaneously Hypertensive Rats
• Role of Neutrophil in Radiation-Induced Colonic Ulcer in SHR and WKY.
• Acute Irradiation Injury and Autonomic Nervous System
• Progressive systemic sclerosis associated with primary small cell carcinoma of the stomach
• Autopsy case of colocalized tumors of hepatocellular carcinoma and malignant lymphoma
• Radiation effect on the Epidennal Growth Factor Binding and on the EGF dependent EGFR-Tyrosine Phosphorylation
• The Effect of Ionizing Radiation on Epidermal Langerhans Cells:A Quantitative Analysis of Autopsy Cases with Radiation Therapy
• The protective effect of IL-11 on radiation induced colitis with rats Eiichiro FUKUDA, Masahiro NAKASHIMA, Kazuko SHICHIJO, Mutsumi
• Adenomyoepithelioma of the Breast A with an Immunohistochemical Study
• Expression of ICAM-1 and Acute Inflammatory Cell Infiltration in the Early Phase of Radiation Colitis in Rats
• Signet-Ring Cell-Like Amphicrine Cell Carcinoma of the Stomach
• The radiation induced apoptosis in spontaneously hypertensive rats jejunum with low-dose irradiation
• Immunohistochemical Study of p53 Overexpression in Radiation-Induced Colon Cancers
• Protease-catalyzed Synthesis of Oligo-L-glutamic Acid from L-Glutamic Acid Diethyl Ester(Food & Nutrition)
• Subarachnoid and Intracerebral Hemorrhage Associated with Necrotizing Angiitis Due to Methamphetamine Abuse : An Autopsy Case
• Bi系酸化物超伝導体のT_cに及ぼすW添加の影響
• Novel Electro-responsive Property of Polyether-polycarbamate Solution
• Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells
• Prolonged Radiation Damage in Rat Colon and Urokinase Expression in Epithelium
• Polyethylene Glycol-Modified Papain Catalyzed Oligopeptide Synthesis from the Esters of L-Aspartic and L-Glutamic Acids in Benzene(Biological Chemistry)
• Stereospecificity in Papain-catalyzed Oligopeptide Synthesis(Biological Chemistry)
• Experimental Radiation Ulcer in Colon and Effects of Anti-Ulcer Drug
• MAGNIFYING ENDOSCOPIC OBSERVATION WITH NARROW BAND IMAGING FOR SPECIALIZED INTESTINAL METAPLASIA IN BARRETT'S ESOPHAGUS WITH SPECIAL REFERENCE TO LIGHT BLUE CRESTS
• Acute Irradiation Injury and Autonomic Nervous System
• Radiation Induced Colonic Ulcer in Spontaneously Hypertensive Rat
• Femoral Head Necrosis in Stroke-Prone Spontaneously Hypertensive Rat

もっと見る 閉じる

スポンサーリンク