Immunohistochemical Study of p53 Overexpression in Radiation-Induced Colon Cancers

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概要

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• The expressions of p53 and proliferating cell nuclear antigen (PCNA) were studied immunohistochemically from paraffin sections of 7 cases (9 lesions) of radiation-induced colon cancer and 42 cases of spontaneous colon cancer. Age distribution of radiation-induced and spontaneous colon cancer were 68.1 years (range, 56 to 77 years) and 67.4 years (range, 31 to 85 years), respectively. Among the radiation-induced colon cancers, there were 3 lesions of mucinous carcinoma (33%), a much higher than found for spontaneous mucinous cancer. Immunohistochemically, p53 protein expression was detected in 7/9 (78%) of radiation-induced cancers and in 23/42(55%) of spontaneous colon cancers. χ^2 analysis found no significant differences between radiation-induced and spontaneous colon cancers in age distribution or p53-positive staining for frequency, histopathology, or Dukes' classification. In radiation colitis around the cancers including aberrant crypts, spotted p53 staining and abnormal and scattered PCNA-positive staining were observed. In histologically normal cells, p53 staining was almost absent and PCNA-positive staining was regularly observed in the lower half of the crypt. In radiation colitis including aberrant glands, cellular proliferation increased and spotted p53 expression was observed. This study suggests that radiation colitis and aberrant glands might possess malignant potential and deeply associate with carcinogenesis of radiation-induced colon cancer.

• 日本放射線影響学会の論文

著者

• Matsuo Isao

  Second Department Of Internal Medicine Nagasaki University School Of Medicine

• MATSUZAKI Sumihiro

  Department of Surgery II,Nagasaki University School of Medicine

• Ito M

  Second Department Of Internal Medicine Nagasaki University School Of Medicine

• Sekine I

  Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute

• Sekine Ichiro

  長崎大学 医歯薬学総合研究科腫瘍診断病理学

• HAYASHI Nobuyuki

  Department of Electronic Engineering Graduate School of Engineering, Osaka University

• ITO MASAHIRO

  Department of Pediatrics, School of Medicine, Mie University

• Matsuzaki S

  Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Gradu

• Ito Masahiro

  Department Of Pathology National Nagasaki Medical Center

• SEKINE Ichiro

  Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu

• Minami Kazunori

  Department of Radiology, Nagasaki Municipal Citizen's Hospital

• Matsuo I

  長崎大学 医学部内科学第2

• Sekine Ichiro

  長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室

• Ito Masahiro

  国立病院長崎医療センター

• MOKARIM ABUL

  Department of Radiology, Nagasaki University School of Medicine

• Mokarim Abul

  Department Of Radiology Nagasaki University School Of Medicine

• Sekine Ichiro

  Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch

• Minami Kazunori

  Department Of Radiology Nagasaki Municipal Citizen's Hospital

• Matsuzaki Sumihiro

  Department Of Surgery Ii Nagasaki University School Of Medicine

• Hayashi Nobuyuki

  Department Of Chemistry Faculty Of Science And Engineering Waseda University

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin

• Ito Masahiro

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Ito Masahiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Ito Masahiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine

• Matsuzaki Sumihiro

  Department of Pathology, Nagasaki University School of Medicine

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