The Role of the Sympathetic Nervous System in Radiation-induced Apoptosis in Jejunal Crypt Cells of Spontaneously Hypertensive Rats

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概要

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• To evaluate the effect of the sympathetic nervous system on radiation-induced apoptosis in jejunal crypt cells, apoptosis levels were compared in spontaneously hypertensive rats (SHR), animals which are a genetic hyperfunction model of the sympathetic nervous system, and normotensive Wistar-Kyoto rats (WKY). SHR and WKY were exposed to whole body X-ray irradiation at doses from 0.5 to 2 Gy. The apoptotic index in jejunal crypt cells was significantly greater in SHR than in WKY at each time point after irradiation and at each dose. WKY and SHR were treated with reserpine to induce sympathetic dysfunction, and were subsequently exposed to irradiation. Reserpine administration to SHR or WKY resulted in a significant suppression of apoptosis. p53 accumulation was detected in the jejunum in both WKY and SHR after irradiation by Western blotting analysis. There were no significant differences in the levels of p53 accumulation in irradiated intestine between WKY and SHR. These findings suggested that hyperfunction of the sympathetic nervous system is involved in the mechanism of high susceptibility to radiation-induced apoptosis of the jejunal crypt cells.

• 日本放射線影響学会の論文

著者

• SHICHIJO Kazuko

  Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Scie

• Matsuo Isao

  Second Department Of Internal Medicine Nagasaki University School Of Medicine

• Sekine I

  Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute

• Sekine Ichiro

  長崎大学 医歯薬学総合研究科腫瘍診断病理学

• ITO MASAHIRO

  Department of Pediatrics, School of Medicine, Mie University

• Ikeda Yuji

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Ikeda Yuji

  Department Of Internal Medicine Saga Medical School

• Ito Masahiro

  Department Of Pathology National Nagasaki Medical Center

• OKAICHI Kumio

  Department of Radiation Biophysics, Nagasaki University Graduate School of Biomedical Sciences

• Okaichi Kumio

  Department Of Radiation Biophysics Atomic Bomb Disease Institute Nagasaki University Graduate School

• Okaichi K

  Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn

• Okaichi Kumio

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Shichijo Kazuko

  Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien

• Naito Shinji

  Department of Molecular Pathology, Atomic Disease Institute

• NAKAMURA Yasuko

  Department of Pediatrics, Ehime University School of Medicine

• MATSUU Mutsumi

  Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu

• SEKINE Ichiro

  Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institu

• Matsuo I

  長崎大学 医学部内科学第2

• Matsuu Mutsumi

  Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien

• Shichijo Kazuko

  長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 病理

• Okaichi Kumio

  長崎大学医学部附属原爆後障害医療研究施設 腫瘍･診断病理学

• Naito Shinji

  Division Of Pathology Research Laboratory National Ureshino Hospital

• Naito Shlnji

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Sekine Ichiro

  長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室

• Ito Masahiro

  国立病院長崎医療センター

• Nakamura Y

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Sekine Ichiro

  Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch

• Shichijo Kazuko

  Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute

• Okaichi Kumio

  Department Of Radiation Biophysics Atomic Bomb Disease Institute

• Nakamura Yasuko

  Department Of Chemistry Of Science Kagoshima University

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagaski University School Of Medicin

• Ikeda Yuji

  Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine

• Ito Masahiro

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Ito Masahiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Ito Masahiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine

• Sekine Ichiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine

• Shichijo Kazuko

  Department of Pathology Atomic Disease Institute, Nagasaki University School of Medicine

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