Signet-Ring Cell-Like Amphicrine Cell Carcinoma of the Stomach

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概要

• 論文の詳細を見る

• A poorly differentiated adenocarcinoma containing diverse components, tubular, signet-ring cell and neuroendocrine elements, in a 79-year-old man is described. Endoscopy examination revealed a Borrmann type IV tumor in the antrum. Histologically, scattered foci of tubular and signet-ring cells and a greater number of neuroendocrine elements were observed. The tumor cells were positive for chromogranin A, neuron specific enolase (NSE) and carcinoembryonic antigen (CEA). Furthermore, about one third of the tumor cells were demonstrated as amphicrine differentiation by double staining with chromogranin A and periodic acid-Schiff (PAS). Amphicrine cell carcinomas with exocrine and endocrine differentiation in the stomach is rare and poor prognosis. The present case suggests that amphicrine cell carcinomas can occur in signet-ring cell morphogenesis, and that a multipotential stem cell is an origin of this unusual variant of neuroendocrine carcinoma.

• 長崎大学の論文

著者

• Matsuo Isao

  Second Department Of Internal Medicine Nagasaki University School Of Medicine

• Ito M

  Second Department Of Internal Medicine Nagasaki University School Of Medicine

• Sekine I

  Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute

• Sekine Ichiro

  長崎大学 医歯薬学総合研究科腫瘍診断病理学

• Matsuzaki S

  Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Gradu

• Alipov Gabit

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Ito Masahiro

  Department Of Pathology National Nagasaki Medical Center

• NAKASHIMA Masahiro

  First Department of Internal Medicine, National Defense Medical College

• Matsuo I

  長崎大学 医学部内科学第2

• Nakashima Masahiko

  Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute

• Sekine Ichiro

  長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室

• Ito Masahiro

  国立病院長崎医療センター

• Gabit Alipov

  Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medi

• Nakashima Masahiko

  First Department of Surgery, Nagasaki University School of Medicine

• Sekine Ichiro

  Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine

• Sekine Ichiro

  Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch

• Ito Masahiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medici

• Ito Masahiro

  Department Of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School Of Medicine

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