Prolonged Radiation Damage in Rat Colon and Urokinase Expression in Epithelium
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概要
- 論文の詳細を見る
Although radiation therapy plays important role in the treatment of gynecological tumors, it may cause radiation injury as a late effect. Several recent reports show that urokinase such as urokinase type plasminogen activator (uPA) contributes to the repair of ulcerative lesions of the colon epithelium. We studied radiation induced enterocolitis using rat animal models. Seventy-two female Wistar rats were irradiated by a single fraction dose of 36Gy at laparotomy. Histological changes and activity of urokinase system were investigated after irradiation. Ulcers were observed in irradiated field in 12 of 19 animals (63%) even at 60th week after irradiation. Urokinase expressions were observed in the margins of active ulcer. Urokinase was thought to play important role in exacerbation of ulcer formation. Expression of uPA was also observed in submucosal glands. Ischaemic changes were not observed in irradiated colon despite sclerosing vasculitis. It is suggested that uPA played reciprocal roles in radiation induced enterocolitis: healing and aggravation of ulcer.
- 長崎大学の論文
著者
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Nagayasu Takeshi
長崎大学 大学院腫瘍外科
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Sekine I
Tissue And Histopathology Section Division Of Scientific Data Registry Atomic Bomb Disease Institute
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Sekine Ichiro
長崎大学 医歯薬学総合研究科腫瘍診断病理学
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Shichijo Kazuko
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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HAYASHIDA Masayuki
Department of Radiology Nagasaki University School of Medicine
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Nakayama Toshiyuki
Division Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Graduat
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Matsuu Mutsumi
Department Of Tumor And Diagnostic Pathology Nagasaki University Graduate School Of Biomedical Scien
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Shichijo Kazuko
長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 病理
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Sekine Ichiro
長崎大学医学部附属原爆後障害医療研究施設 生体材料保存室
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Sekine Ichiro
Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine
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Nakayama Toshiyuki
Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences
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Sekine Ichiro
Division Of Tumor And Diagnostic Pathology Atomic Disease Institute Nagasaki University Graduate Sch
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Shichijo Kazuko
Department Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute
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Sekine Ichiro
Tissue And Histopathology Section Division Of Scientific Data Registry Nagasaki University Graduate
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Shichijo Kazuko
Department of Pathology Atomic Disease Institute, Nagasaki University School of Medicine
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