Correlation between Angiogenesis and p53 Expression in Lung Adenocarcinoma of Young Patients

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概要

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• Lung cancer commonly occurs in individuals who are 60 years of age or older. Lung cancer in patients younger than 40 years of age is rare and is often advanced when discovered. However, the biological features of lung cancer in young adults have not yet been fully elucidated. This study was conducted to determine the role of p53 expression and neoangiogenesis in lung adenocarcinomas of young patients. Lung adenocarcinomas, which were surgically resected from 20 patients younger than 40 years of age between 1977 and 1996, were compared with lung adenocarcinomas selected with random sampling from 45 patients older than 60 years of age. The expression of p53, vascular endothelial growth factor (VEGF), CD34, a marker for vascular endothelial cells, and proliferating cell nuclear antigen (PCNA) were studied immunohistochemically in both young and elderly patient groups. Lung adenocarcinomas with p53-positive staining showed higher expression of VEGF protein than p53-negative tumors in both the young and the elderly groups. However, the intratumoral microvessel count was significantly higher in the p53-positive young group than in the elderly group. The percentage of VEGF-positive cells correlated significantly with intratumoral microvessel counts in the young group. The survival rate tended to be poorer in patients with a high VEGF labeling index and p53-positive staining than in other young patients. Lung adenocarcinoma occurring in young patients tends to have a poorer prognosis, and angiogenesis of lung adenocarcinoma in young patients is more closely correlated with p53 expression than in elderly patients.

• Tohoku University Medical Pressの論文
• 2009-02-01

著者

• Tsuji T

  長崎大学 医学部第二内科

• Nagayasu Takeshi

  長崎大学 大学院腫瘍外科

• Nagayasu Takeshi

  Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences

• Nagayasu Takeshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Tashiro Takayoshi

  長崎大学 第二内科

• Nagayasu Takeshi

  長崎大学 医学部第二内科

• Nagayasu Takeshi

  長崎大学 医歯薬学総合研究科腫瘍外科

• Yamaguchi H

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Yamaguchi Hiroyuki

  長崎大学 医歯薬総研究腫瘍外科学

• MINAMI Hiroyuki

  Department of Fixed Prosthodontics, Graduate School of Medical and Dental Sciences, Kagoshima Univer

• Tagawa Y

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yasutake Toru

  長崎大学 医歯薬学総合研究科腫瘍外科学

• Yasutake Toru

  Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences

• Tamaru Naoe

  Department Of Pathology Nagasaki University Hospital

• 辻 孝

  Hokkaido Univ. Sapporo Jpn

• Nagayasu Takeshi

  Division Of Surgical Oncology Nagasaki University Graduate School

• TSUCHIYA Tomoshi

  Division of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences

• TAKESHITA HIROAKI

  Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Gra

• HIDAKA SHIGEKAZU

  Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Gra

• YANO HIROSHI

  Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Gra

• KONDOU MASAMICHI

  Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedi

• IWASAKI KEISUKE

  Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedi

• Minami Hiroyuki

  Department Of Surgery Sasebo City General Hospital

• Tsuji Takashi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Tsuchiya Tomoshi

  Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences

• Shindo Hisakazu

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Nakayama Toshiyuki

  Division Of Tumor And Diagnostic Pathology Atomic Bomb Disease Institute Nagasaki University Graduat

• Yano Hiroshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Iwasaki Keisuke

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Kondou Masamichi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Nagayasu Takeshi

  Department Of Pathology Nagasaki University Graduate School Of Biomedical Sciences

• Takeshita Hiroaki

  Division Of Surgical Ontology Nagasaki University Graduate School Of Biomedical Sciences

• Nagayasu Takeshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Hidaka Shigekazu

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Tsuchiya Tomoshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yasutake Toru

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Taniguchi Yoshitaka

  First Department Of Surgery Nagasaki University School Of Medicine

• Yamaguchi Hiroyuki

  First Department Of Surgery Nagasaki University School Of Medicine

• Nagayasu Takeshi

  Division Of Surgical Ontology Nagasaki University Graduate School Of Biomedical Sciences

• Nagayasu Takeshi

  Department Of First Surgery Nagasaki University Graduate School Of Biomedical Sciences

• Tsuchiya Tomoshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yano Hiroshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Nagayasu Takeshi

  長崎大学 大学院医歯薬学総合研究科腫瘍外科第1外科

• Iwasaki Keisuke

  Division of Pathology, Sasebo City General Hospital

• TAKESHITA Hiroaki

  Division of Surgical Oncology and Department of Surgery, Nagasaki University Hospital

• NAGAYASU Takeshi

  Division of Surgical Oncology and Department of Surgery, Nagasaki University Hospital

• TSUCHIYA Tomoshi

  Division of Surgical Oncology and Department of Surgery, Nagasaki University Hospital

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