High Level Expression of Platelet-derived Endothelial Cell Growth Factor predicts Good Prognosis in Colorectal Cancer Patients

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概要

• 論文の詳細を見る

• Platelet-derived endothelial cell growth factor (PD-ECGF) is one of the angiogenic factors. PD-ECGF expression is elevated in colorectal carcinoma, but its prognostic value does not reach a consensus. The aim of this study is to clarify the prognostic value of the PD-ECGF expression in colorectal carcinomas. PD-ECGF expression was measured by enzyme- linked immunosorbent assay in frozen materials from 71 colorectal cancer patients who had recived curative resection. Patients were divided into high expression and low expression groups based on cut-off value. Correlations among PD-ECGF expression, clinicopathologic features, and disease-free interval were studied by univariate and multivariate analysis. To evaluate the origin of PD-ECGF, serial sections of 71 tumors were stained for PD-ECGF and CD68. PD-ECGF expression in normal mucosa was 34.4 ﾂｱ 15.5 (Units/mg protein) and the cut-off value was 65.4 (mean+2SD). There were no significant correlations between clinicopathological features and PD-ECGF expression. The disease-free interval for high PD-ECGF expression group was significantly longer than that of low expression group (P=0.006). A multivariate Cox's regression analysis revealed a high PD-ECGF expression as an independent factor for better outcome. In immunohistochemical study, almost all tumor cells were negative for PD-ECGF, but stromal macrophages were predominantly positive for PD-ECGF. In conclusion, the PD-ECGF expression measured in this study was derived from stromal macrophages. High PD-ECGF expression was a predictor for favorable outcome after curative resection for colorectal cancer.

• 長崎大学の論文

著者

• Tsuji T

  長崎大学 医学部第二内科

• Nagayasu Takeshi

  長崎大学 大学院腫瘍外科

• Tashiro Takayoshi

  長崎大学 第二内科

• Yamaguchi H

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Yamaguchi Hiroyuki

  長崎大学 医歯薬総研究腫瘍外科学

• Tagawa Y

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yasutake Toru

  長崎大学 医歯薬学総合研究科腫瘍外科学

• Tamaru Naoe

  Department Of Pathology Nagasaki University Hospital

• 辻 孝

  Hokkaido Univ. Sapporo Jpn

• AYABE HIROYOSHI

  First Department of Surgery, Nagasaki University School of Medicine

• Sawai T

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Sawai Terumitsu

  First Department Of Surgery Nagasaki University School Of Medicine

• TSUJI TAKASHI

  First Department of Surgery, Nagasaki University School of Medicine

• Tsuji Takashi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Shindo Hisakazu

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Nakashima Atsushi

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Yano Hiroshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Tsuji Takashi

  Department Of Material Chemistry Graduate School Of Engineering Kyoto University

• Shibasaki Shinichi

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Ayabe Hiroyoshi

  First Department Of Surgery Nagasaki University School Of Medicine

• Ayabe Hiroyoshi

  The First Department Of Surgery Nagasaki University School Of Medicine

• Ayzbe Hiroyoshi

  First Department Of Surgery Nagasaki University School Of Medicine

• Nakamura Akihiro

  Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences

• Nagayasu Takeshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Hidaka Shigekazu

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Taniguchi Yoshitaka

  First Department Of Surgery Nagasaki University School Of Medicine

• Yamaguchi Hiroyuki

  First Department Of Surgery Nagasaki University School Of Medicine

• Ayabe Hiroyoshi

  Department Of First Surgery Nagasaki University School Of Medicine

• Nagayasu Takeshi

  Division Of Surgical Ontology Nagasaki University Graduate School Of Biomedical Sciences

• Tsuchiya Tomoshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yano Hiroshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Nagayasu Takeshi

  長崎大学 大学院医歯薬学総合研究科腫瘍外科第1外科

• Fukuoka Hidetoshi

  Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences

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