Biological Differences Between. Polypoid and Nonpolypoid Growth Types of Colorectal Cancer
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概要
- 論文の詳細を見る
Background- Two distinct morphologic types of colorectal cancer have been described in recent studies: polypoid growth type (PG-type) and nonpolypoid growth type (NPG-type). Materials and Methods- We investigated possible biological and clinical differences between 37 PG-type and 156 NPGtype cancers using both univariate and multivariate analyses (logistic and Cox regression models). Results- Unlike NPG-type cancers, PG-type cancers had a high proportion of well-differentiated adenocarcinoma cells, a high likelihood of being early colorectal cancers (carcinoma in situ and cancer invades submucosa), and a low frequency of lymph node metastasis. On average, such PG-type cancers also carried a better prognosis than NPG-type cancers (P=0.01). In particular, PG-type cancer patients with stage IV tumors had a better prognosis than NPG-type cancer patients (P=0.02). In fact, after performing a Cox regression analysis, we found that colorectal cancer growth type is an independent prognostic variable, separate from histologic type or stage. Conclusions- PG-type colorectal cancer is less aggressive and has a favorable prognosis compared to NPG-type cancer.
- 長崎大学の論文
著者
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Tsuji T
長崎大学 医学部第二内科
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Nagayasu Takeshi
長崎大学 大学院腫瘍外科
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Yamaguchi H
Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu
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Yamaguchi Hiroyuki
長崎大学 医歯薬総研究腫瘍外科学
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Tagawa Y
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Yasutake Toru
長崎大学 医歯薬学総合研究科腫瘍外科学
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Tamaru Naoe
Department Of Pathology Nagasaki University Hospital
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辻 孝
Hokkaido Univ. Sapporo Jpn
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Sawai T
Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu
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Sawai Terumitsu
First Department Of Surgery Nagasaki University School Of Medicine
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JIBIKI Masaaki
The First Department of Surgery, Nagasaki University School of Medicine
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Tsuji Takashi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Nakashima Atsushi
Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu
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Yano Hiroshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Jibiki Masaaki
The First Department Of Surgery Nagasaki University School Of Medicine
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Ayabe Hiroyoshi
First Department Of Surgery Nagasaki University School Of Medicine
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KUROSAKI NOBUKO
First Department of Surgery, Nagasaki University School of Medicine
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Ayzbe Hiroyoshi
First Department Of Surgery Nagasaki University School Of Medicine
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Kurosaki Nobuko
First Department Of Surgery Nagasaki University School Of Medicine
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Nagayasu Takeshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Tsuchiya Tomoshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Yano Hiroshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Nagayasu Takeshi
長崎大学 大学院医歯薬学総合研究科腫瘍外科第1外科
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