Prognostic Value of Circulating CA 19-9 in Colorectal Cancer Patients

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概要

• 論文の詳細を見る

• Aims: We examined the preoperative serum levels of sialyl Lewisa (CA19-9) and carcinoembryonic antigen (CEA) in 262 colorectal cancer patients, in order to clarify whether or not the prognostic value of CA19-9 after curative surgery is superior to that of CEA. Patients and Methods: The patients were divided into two groups: low or high antigen groups (higher or lower than a selected diagnostic-based cut-off value). For evaluation of the prognostic value of CA19-9 and CEA, the disease-free interval was studied. Results: The disease-free interval of patients with a high serum levels of CA19-9 or CEA was significantly shorter than for those patients with a low serum level of the particular antigen (P<0.0001 and P=0.0009, respectively). The disease-free interval of patients with stage I/II tumors who had a high CA19-9 level was significantly shorter than in those patients with stage I/II tumors with low CA19-9 levels (P=0.0020). In contrast, the disease-free interval of patients with stage I/II tumors who had a low or high CEA level did not differ. Cox s regression analysis revealed that a high serum level of CA19-9 or CEA was an independent predictor for short disease-free interval after curative surgery, separate from stage (Hazard ratio=2.65 or 1.68, respectively, versus a low serum level of each respective antigen) . Conclusions: These data suggest that the preoperative serum level of CA19-9 was a stronger prognostic factor after curative surgery than CEA. Furthermore, in contrast to CEA, CA19-9 provides more prognostic information than that obtained by conventional staging methods in patients with stage I/II tumors.

• 長崎大学の論文

著者

• Tsuji T

  長崎大学 医学部第二内科

• Nagayasu Takeshi

  長崎大学 大学院腫瘍外科

• Yamaguchi H

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Yamaguchi Hiroyuki

  長崎大学 医歯薬総研究腫瘍外科学

• Tagawa Y

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yasutake Toru

  長崎大学 医歯薬学総合研究科腫瘍外科学

• TSUJI Takashi

  Department of Industrial Science and Technology, Science University of Tokyo

• Tamaru Naoe

  Department Of Pathology Nagasaki University Hospital

• 辻 孝

  Hokkaido Univ. Sapporo Jpn

• Nakagoe Tohru

  First Department Of Surgery Nagasaki University School Of Medicine

• Sawai T

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Sawai Terumitsu

  First Department Of Surgery Nagasaki University School Of Medicine

• JIBIKI Masaaki

  The First Department of Surgery, Nagasaki University School of Medicine

• Tsuji Takashi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Nakashima Atsushi

  Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu

• Yano Hiroshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Tsuji Takashi

  Department Of Biological Science And Technology Faculty Of Industrial Science And Technology Tokyo U

• Jibiki Masaaki

  The First Department Of Surgery Nagasaki University School Of Medicine

• Ayabe Hiroyoshi

  First Department Of Surgery Nagasaki University School Of Medicine

• KUROSAKI NOBUKO

  First Department of Surgery, Nagasaki University School of Medicine

• Sawai Terumitsu

  School of Allied Medical Science, Nagasaki University

• Ayzbe Hiroyoshi

  First Department Of Surgery Nagasaki University School Of Medicine

• Kurosaki Nobuko

  First Department Of Surgery Nagasaki University School Of Medicine

• Nagayasu Takeshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Tsuchiya Tomoshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Yano Hiroshi

  Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica

• Nagayasu Takeshi

  長崎大学 大学院医歯薬学総合研究科腫瘍外科第1外科

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