Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma.
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概要
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BACKGROUND: The aim of this study was to compare the effects of laserphyrin-PDT (L-PDT) on biliary cancer with those of the conventional photosensitizer, photofrin-PDT (P-PDT). METHODS: An animal tumor model was established by inoculation of NOZ cells in 4-week-old male BALB/c mice. The laser light wavelength was set at 630 nm for P-PDT and 660 nm for L-PDT, at a frequency of 10 Hz. Each group received a total energy flux of 60 J/cm(2). The proportion of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling)-positive cells, expression of VEGF (vascular endothelial growth factor) and the PCNA (proliferating cell nuclear antigen)-labeling index (LI) were assessed after PDT. RESULTS: L-PDT had significantly more potent apoptotic effects at 48 and 72 h after light exposure compared with P-PDT (P < 0.001). The mean PCNA-LI was significantly lower in the L-PDT group than the P-PDT group and the index was significantly lower at several time points after PDT (6, 12, 24, 48 and 72 h after laser light exposure) in the L-PDT than P-PDT (P < 0.001 vs. control). The cell proliferative activity was significantly decreased at 12 and 24 h after P-PDT compared with the control (P < 0.001). VEGF expression was significantly higher at 3 h after L-PDT compared with the control (P < 0.05), whereas it was significantly higher at many time points after P-PDT (3, 6, 48 and 72 h; P < 0.05 vs. control). CONCLUSIONS: L-PDT is a better approach for biliary cancer than the conventional P-PDT, based on its potent apoptotic and cytostatic effects.
- Springer Verlagの論文
- 2011-07-01
著者
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Nagayasu Takeshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Nagayasu Takeshi
長崎大学 医学部第二内科
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Nagayasu Takeshi
長崎大学 医歯薬学総合研究科腫瘍外科
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Tamaru Naoe
Department Of Pathology Nagasaki University Hospital
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Nagayasu Takeshi
Division Of Surgical Oncology Nagasaki University Graduate School
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Nakashima Atsushi
Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu
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Nonaka Takashi
Division Of Cell Biology And Biochemistry Department Of Basic Medical Science Institute Of Medical S
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Isomoto Hajime
Department Of Endoscopy Nagasaki University Hospital
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Nakayama Toshiyuki
Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences
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Nanashima Atsushi
Division Of Surgical Oncology And Department Of Surgery Nagasaki University Hospital
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Nakamura Akihiro
Division Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences
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Nagayasu Takeshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Nagayasu Takeshi
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Nakamura Akihiro
Division Of Surgical Oncology Nagasaki University Graduate School
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NONAKA Mihoko
Division of Surgical Oncology, Department of Regenerative Oral Surgery, Nagasaki University Graduate
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UEHARA Masataka
Division of Surgical Oncology, Department of Regenerative Oral Surgery, Nagasaki University Graduate
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NONAKA Yoshikazu
Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedi
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Nonaka Mihoko
Division Of Surgical Oncology Department Of Regenerative Oral Surgery Nagasaki University Graduate S
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Nonaka Yoshikazu
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Isomoto Hajime
Department Of Gastroenterology And Hepatology Nagasaki University Graduate School Of Biomedical Scie
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Nagayasu Takeshi
長崎大学 大学院医歯薬学総合研究科腫瘍外科第1外科
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Uehara Masataka
Division Of Surgical Oncology Department Of Regenerative Oral Surgery Nagasaki University Graduate School Of Biomedical Sciences
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NAGAYASU Takeshi
Division of Surgical Oncology and Department of Surgery, Nagasaki University Hospital
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