Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53

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概要

• 論文の詳細を見る

• To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 × g) induced the accumulation of p53 in the human glioblastoma cell line A172 after 3 h of incubation. Low-dose (0.5 Gy) irradiation to the cells accumulated p53 1.5 h after irradiation, and induced Waf-1 and Bax. Under the condition of hypergravity (20 × g), the peak of p53 accumulation was shifted from 1.5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells.

• 日本放射線影響学会の論文

著者

• OHNISHI Takeo

  Department of Biology, School of Medicine, Nara Medical University

• Ohnishi Ken

  Department Of Biology Nara Medical University

• OKUMURA Yutaka

  Department of Radiation Biophysics, atomic Disease Institute, Nagasaki University School of Medicine

• Ohnishi Takeo

  Department Of Biology Nara Medical University

• OKAICHI Kumio

  Department of Radiation Biophysics, Nagasaki University Graduate School of Biomedical Sciences

• Okaichi Kumio

  Department Of Radiation Biophysics Atomic Bomb Disease Institute Nagasaki University Graduate School

• Okaichi K

  Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn

• Okaichi Kumio

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Okaichi Kumio

  長崎大学医学部附属原爆後障害医療研究施設 腫瘍･診断病理学

• Okumura Y

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Okumura Yutaka

  Radiation Biophysics Atomic Bomb Sisease Inst. Nagasaki Univ.

• Ohnishi Takeshi

  Dept. Biology Nara Med. Univ.

• Usui Aya

  Department of Radiation Biophysics, Radiation Effect Research Unit, Atomic Bomb Disease Institute, N

• Okumura Yutaka

  Department Of Biostatistics Scientific Data Center For The Atomic Bomb Disaster Nagasaki University

• Usui Aya

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Okaichi Kumio

  Department Of Radiation Biophysics Atomic Bomb Disease Institute

• Ohnishi Takeo

  Nara Medical University

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