Hypergravity Induces Phosphorylation of p53 at Serine 15, but not an Expression of p53-downstream Genes

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概要

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• We investigated the p53 signaling pathway induced by hypergravity in the human glioblastoma cell line A 172. Hypergravity (20×g) induced the accumulation of p53 and the phosphorylation of p53 at Ser-15. The phosphorylation of p53 with hypergravity was not inhibited by wortmannin, the PI3-kinase inhibitor. This indicated that the p53 signal pathway induced by hypergravity is different from other p53 signal pathways, such as that of the DNA damage signal. Hypergravity did not induce an expression of the genes Waf-1 or Bax, located downstream from p53. We also examined the expression of genes with hypergravity by using a DNA microarray containing oligo DNA from 30,000 human genes. Hypergravity (20×g, 6h) did induce the expression of some genes concerned with the cell signaling pathway and cytoskeleton of the cell, but not any of the p53-downstream genes. DNA microarray revealed the induction of many genes to enable the cells to adapt to the hypergravity environment.

• 日本放射線影響学会の論文
• 2004-10-10

著者

• OKUMURA Yutaka

  Department of Radiation Biophysics, atomic Disease Institute, Nagasaki University School of Medicine

• OKAICHI Kumio

  Department of Radiation Biophysics, Nagasaki University Graduate School of Biomedical Sciences

• Okaichi Kumio

  Department Of Radiation Biophysics Atomic Bomb Disease Institute Nagasaki University Graduate School

• Okaichi K

  Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn

• Okaichi Kumio

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Okaichi Kumio

  長崎大学医学部附属原爆後障害医療研究施設 腫瘍･診断病理学

• Okumura Y

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Okumura Yutaka

  Radiation Biophysics Atomic Bomb Sisease Inst. Nagasaki Univ.

• IDE Miwa

  Department of Radiation Biophysics, Radiation Effect Research Unit, Atomic Bomb Disease Institute, N

• Usui Aya

  Department of Radiation Biophysics, Radiation Effect Research Unit, Atomic Bomb Disease Institute, N

• Okumura Yutaka

  Department Of Biostatistics Scientific Data Center For The Atomic Bomb Disaster Nagasaki University

• Usui Aya

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Ide Miwa

  Department Of Radiation Biophysics Radiation Effect Research Unit Atomic Bomb Disease Institute Naga

• Okaichi Kumio

  Department Of Radiation Biophysics Atomic Bomb Disease Institute

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