A Special Section : The Radioadaptive Response

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概要

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• PREFACEDr. Sheldon Wolf and his colleagues in the USA proposed the use of the term "radioadaptive response" about 1980. A priming irradiation with a low dose or delivered at a low dose rate was observed to depress the biological effects induced by a subsequent high dose irradiation. This phenomenon had already been observed after exposures to UV light and to heat. UV-reactivation had been described, and this meant that UV-irradiated phage had higher survival rates in Escherichia coli host cells which had been irradiated with a low dose of UV light prior to infection. Lower survival rates were seen for phage in host cells which had not been exposed to UV prior to infection. In the case of heat, cells exposed to a mild heat treatment acquired thermotolerance against subsequent severe heat exposures. The development of this thermotolerance was shown to depend on the induction of heat shock proteins. Therefore, when the first reports of the radioadaptive response were made, scientists were already aware of such a phenomenon. In addition, this adaptive behavior can be considered quite similar to the immune response which is initiated by a weak exposure to an antigen.Organisms on the earth exist and adapt to environmental changes through the aid of many types of biological functions. There is currently no answer to the question of whether many different organisms can adapt and survive by using the same adaptive mechanisms. However, this is a very interesting area for science to focus on. In this special issue, recent papers are presented discussing the radioadaptive response. These papers were presented in a workshop at the annual meeting of the Japanese Radiation Research Society (Dr. T. Norimura, president) in Kitakyushu City in November, 2008. I hope these manuscripts will provide useful and helpful information for those interested in current and future progress in the study of the radioadaptive response.Translated and modified from Radiat. Biol. Res. Comm. Vol.43(4); 408, (2008, in Japanese).

• Journal of Radiation Research 編集委員会の論文
• 2009-09-16

著者

• Ohnishi Takeo

  Department Of Biology Nara Medical University

• Ohnishi Takeo

  Department Of Biology Nara Medical University School Of Medicine

関連論文

• The Foci of DNA Double Strand Break-recognition Proteins Localize with γH2AX after Heat Treatment
• DNA Damage Recognition Proteins Localize along Heavy Ion Induced Tracks in the Cell Nucleus
• Molecular Mechanisms Involved in Adaptive Responses to Radiation, UV light, and Heat
• Impact of the p53 Status of the Tumor Cells on the Effect of Reactor Neutron Beam Irradiation, with Emphasis on the Response of Intratumor Quiescent Cells
• High LET Heavy Ion Radiation Induces p53-Independent Apoptosis
• High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation
• The Biology of Heat-induced DNA Double-Strand Breaks
• Time Course and Spacial Distribution of UV Effects on Human Skin in Organ Culture
• Development of thermotolerance requires interaction between polymerase-β and heat shock proteins
• Recent Advances in the Biology of Heavy-Ion Cancer Therapy
• ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating
• Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors : its Independency of p53 Status
• Inhibition in a microgravity environment of the recovery of Escherichia coli cells damaged by heavy ion beams during the NASDA ISS Phase I Program of NASA Shuttle/Mir Mission No. 6
• Effects of p53 Status and Wortmannin Treatment on Potentially Lethal Damage Repair, with Emphasis on the Response of Intratumor Quiescent Cells
• Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors : its independence of p53 status
• コンピュータによるイメージ加工と温熱誘導γH2AXフォーカスの解析
• p53-Dependent Signal Transduction Induced by Stress
• Cell growth and morphology of Dictyostelium discoideum in space environment
• Cell growth and morphology of Dictyostelium discoideum in space environment
• Restraint Plus Water-immersion Stress (RWIS)-induced Stomach Ulcers in Mice are Depressed by a Conditioning Heat Treatment
• Expression of p53-Regulated Genes in Cultured Mammalian Cells After Exposure to A Space Environment
• Light-Induced Anthocyanin Reduces the Extent of Damage to DNA in UV-Irradiated Centaurea cyanus Cells in Culture
• The effect of clinorotation on vestibular compensation in upside-down swimming catfish
• Vanguards of Paradigm Shift in Radiation Biology: Radiation-Induced Adaptive and Bystander Responses
• Radiation-Induced Adaptive Responses and Bystander Effects
• DNA Damage Formation and p53 Accumulation in Mammalian Cells Exposed to the Space Environment
• Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status
• p53遺伝子背景に関係ないHSPを介したあらかじめの温熱処理による温熱抵抗性および放射線抵抗性の獲得
• The Significance of the Study about the Biological Effects of Solar Ultraviolet Radiation using the Exposed Facility on the International Space Station
• DNA-Damaging Agents Induce the 72-kD Heat Shock Protein in SV40 Transformed Normal Human Fibroblasts
• Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53
• The Biological Effects of Space Radiation during Long Stays in Space
• Mutation Frequency of Plasmid DNA and Escherichia coli Following Long-term Space Flight on Mir
• The Role of p53 Molecule in Radiation and Hyperthermic Therapies
• Analysis of Apoptosis-related Gene Expression after X-ray Irradiation in Human Tongue Squamous Cell Carcinoma Cells Harboring Wild-type or Mutated p53 Gene
• Detection of DNA Damage Induced by Space Radiation in Mir and Space Shuttle
• Mutation frequency of Dictyostelium discoideum sporcs exposed to the spase environment
• Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G2/M Phase-dependent
• DNA ligase IV is a potential molecular target in ACNU sensitivity
• A Special Section : The Radioadaptive Response
• 細胞の生死にかかわる温熱誘導シグナル伝達経路
• Preface : Space Radiation Biology
• Postural control under clinorotation in upside-down catfish, Synodontis nigriventris
• Relationship between frequency of upside-down posture and space size around upside-down catfish, Synodontis nigriventris
• 大腸菌における紫外線誘発SOS反応の3-アミノベンツアミドによる抑制〔英文〕
• Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G_2/M Phase-dependent
• Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with γH2AX in the nucleus after heat treatment
• Studies about Space Radiation Promote New Fields in Radiation Biology
• Biological Effects of Space Radiation
• 抗トリパノゾ-マ薬品,Ro7-1051,の大腸菌における突然変異原性〔英文〕

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