抗トリパノゾ-マ薬品,Ro7-1051,の大腸菌における突然変異原性〔英文〕
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概要
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The effect of an anti-trypanosomal drug, Ro 7-1051, on killing, mutation induction and prophage induction activities in Escherichia coli has been investigated. A radiation sensitive strain, NG30(recA-), was more sensitive for killing than the wild type strain, H/r30R, and the another radiation-sensitive strain, Hs30R(uvrA-). The killing effect on Hs30R was almost the same as that on H/r30R. Ro 7-1051 induced mutation (arg-→arg+) in both Hs30R and H/r30R strains, while no significant increase of mutation frequency was detected in NG30 strain. The prophage induction was hardly detected from both E, coli W3110(λ) and W3110(λ ind8) strains. The characteristics of lesion of DNA induced by Ro 7-1051 are discussed.
- Genetics Society of Japanの論文
著者
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Ohnishi Takeo
Department Of Biology Nara Medical University
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NOZU Keiichi
Department of Biology, Nara Medical University
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INOKI Shozo
Department of Parasitology Nara Medical University
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大西 武雄
Department of Biology Nara Medical University
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OHASHI Yasuhiro
Department of Biochemistry, Nara Medical University.
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NOZU Keiichi
Department of Biology Nara Medical University
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