ランタン連続経口投与ラットにおけるカルシウム及びリンの代謝について

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In the present study, we examined the effects of a rare earth element, lanthanum (La) on the excretion into the urine and feces as well as the distribution of calcium (^<45>Ca) and phosphorus (^<32>P) in the liver, pancreas, spleen, kidney, lung, heart, thymus, brain, bone and blood of male rats. The experiments were performed using 5 rats in each group. Lanthanum chloride (LaCl_3) was administered orally at a dose of 100 mg/rat/d as La for 5 weeks (La-A group). ^<45>Ca and ^<32>P were administered orally or intravenously once, and following the administration, the urine and feces were collected daily for 8 consecutive days. As a result, the amount of oral ^<45>Ca and ^<32>P excreted into the feces in the La-A group increased remarkably compared with that of the control group (41→91% and 26→99%, respectively), whereas ^<45>Ca and ^<32>P excreted into the urine in the La-A group was reduced (9.5→0.2% and 28→0.3%, respectively). However, the excretion patterns in the urine and feces and the distribution of ^<45>Ca and ^<32>P in the body of rats given La, were similar to those of the control rats after the stop of the La administration (La-B group). The levels of ^<45>Ca and ^<32>P in the body for 8 d after their administration was highest in the control group, followed by the La-B group, and lowest in the La-A group. Moreover, in the La-A group, the levels of ^<45>Ca and ^<32>P in each organ decreased by 1/2 to 1/75 compared with those in the control rats, but there was no significant difference between the control group and the La-B group. However, the excretion patterns in the urine and feces and the distribution of ^<45>Ca and ^<32>P in the La-A group was similar to those of the control group when ^<45>Ca and ^<32>P were administered intravenously. These results suggest that La inhibits the uptake of ^<45>Ca and ^<32>P temporarily, and that the action is reversible.
公益社団法人日本薬学会の論文
1994-02-28

ランタン連続経口投与ラットにおけるカルシウム及びリンの代謝について

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