有害性金属の衛生化学的研究(第3報)カドミウム投与時における, カドミウムの体内分布, 排泄と生体におけるカルシウムおよびリン酸の消長について

概要

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Following the preceeding work on the acute and subacute toxicity tests of cadmium chloride, metabolism and organ distribution of cadmium chloride in rats were investigated after continuous oral administration of 5 or 20 mg/kg/day of cadmium chloride for 30 days. Most of the administered cadmium chloride was excreted in feces and only less than 0.1% was detected in urine. The amount of accumulation of cadmium chloride was highest in the liver, followed by kidney, pancreas, and spleen in that order. Examination of calcium and phosphate excreted in urine and feces showed that the amount of discharged calcium increased markedly in proportion to that taken, while the amount of phosphate excreted in urine and feces decreased. As for the distribution pattern of calcium and phosphate, a clear change could not be observed in the group administered cadmium.
公益社団法人日本薬学会の論文
1973-04-30