Chemical Forms of Nickel in Rat Plasma, Kidney Cytosol and Urine after Administration of ^<63>NiCl_2

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The binding of ^<63>Ni to low-molecular-weight constituents of rat plasma, kidney cytosol and urine has been investigated in vivo and in vitro. Comparative tissue distribution and excretion of ^<63>Ni in rats after administration of ^<63>NiCl_2 through various routes revealed that among rat organs, the kidney showed the highest affinity for ^<63>Ni and that radio-nickel was excreted easily into the urine by way of the kidney. Sephadex G-25 and G-200 gel chromatographies of plasma, kidney cytosol and urine after iv or po administration of ^<63>NiCl_2 demonstrated that a major component of nickel metabolite in the rat urine may originate from one of three Ni-complexes with low molecular weight in the plasma and kidney cytosol. The behaviors of Ni-complex on thin layer chromatography and Sephadex G-25 gel chromatography suggested that one of the metabolites in the rat urine after iv or po administration of ^<63>NiCl_2 existed as a complex of nickel with a picrate-forming substance resembling creatine-related substances.
公益社団法人日本薬学会の論文
1989-02-28