セレン関連化合物に関する研究(第2報)セレン酸(Na_2^<75>SeO_4)の生体運命についてその1

概要

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Whole body turnover, excretion and time-distribution of selenium in rats were examined after administration of Na_2^<75>SeO_4. It was found that 60% of the selenium administered was absorbed through the intestine and excreted mainly in urine. The excretion of ^<75>Se-containing metabolite in the respiratory was confirmed. Selenium was rapidly accumulated in the liver as the first target organ, and subsequently moved into various organs through the blood. The biological half life of the C period was found to be 22.44 days which indicates that excretion of selenium in various tissues is comparatively rapid. Studies on the behavior of selenium in blood using Na_2^<75>SeO_4 demonstrated that selenium passes through the membrance of red blood cells and combines with hemoglobin.
社団法人日本薬学会の論文
1972-12-31