セレン関連化合物に関する研究(第4報)セレン酸ナトリウムの急性ならびに亜急性毒性についてその2

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In continuation of previous studies on the subacute toxicity of sodium selenate, distribution of selenium in the tissues, time-excretion of selenium in urine and feces and biochemical examinations of serum were examined after administration of sodium selenate to rats at continuous oral dosage of 1 and 5 mg/kg/day for 30 days. It was found that excretion of selenium in urine was 2-5 times of that in feces and time-excretion patterns of selenium in urine were markedly different according to sexes. The accumulation of sodium selenate was the highest in the liver, followed by the kidney, testis, lung, and spleen, in that order, but the concentration of accumulated selenate was the highest in the kidney, followed by the liver, spleen, and pancrease, in that order. After continuous administration of sodium selenate for 30 days, rats became anemic due to decrease in the number of red blood cells, amount of hemoglobin and hematocrit value. Female rats in the groups given 5 mg/kg/day showed lower values of protein, and A/G ratio, and higher value of GPT compared with the control group. It was recognized that accumulated selenium in the liver produced subacute yellow liver atrophy due to damage of liver function.
社団法人日本薬学会の論文
1974-04-30