アミノ酸の亜硝酸イオン共存下における塩素処理による変異原性の発言

概要

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Mutagenicity after aqueous chlorination of amino acids in the presence of nitrite was investigated by the Ames Salmonella/microsome assay.After aqueous chlorination of L-tryptophan and L-phenylalanine with higher concenration of chlorine, chlorination products from L-tryptophan showed to be mutagenic.The behaviors of these mutagenic activities using strains highly detected nitroarenes and aminoarenes suggested that base-pair change and frame-shift mutagens such as nitroarenes are produced by aqueous chlorination of L-tryptophan in the presence of nitrite.It was recognized that after aqueous chlorination of L-phenylalanine with lower concentration of chlorine in the presence of nitrite, base-pair change and frame-shift mutagens as well as nitroarenes may be produced.
社団法人　日本水環境学会の論文
1995-05-10