有害性金属の衛生化学的研究(第7報)カドミウム連続経口投与時の骨構成成分ならびに酵素活性について

概要

論文の詳細を見る
Chemical composition of the bone and the activity of the enzyme responsible for bone resorption in rats were examined after oral administration of cadmium chloride for various lengths of time. The amount of sialic acid and hexose in the bone of rats treated with cadmium increased over that of control rats, but the amount of hexosamine and uronic acid did not change. The amounts of calcium and phosphorus in the bone decreased markedly after exposure of the animals to cadmium chloride for 6 months. In the rats which treated with cadmium for 6 months, the activities of acid phosphatase, β-glucuronidase, β-N-acetylglucosaminidase, and β-galactosidase in the bone all increased over those of the control rats. These results suggested that resorption of diaphysial bone of rats were accelerated by the continuous oral ingestion of cadmium.
社団法人日本薬学会の論文
1978-02-28