ポリ塩化トリフェニル(PCT)の長期投与によるマウス体内における蓄積(第2報)

概要

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Male mice were maintained on the diet containing 20 and 100 ppm of polychlorinated terphenyls (PCT) for 20 months, and PCT accumulated in liver, kidney, brain, skin and adipose tissue were analyzed at the end of 12 th and 18 th months. It was observed that PCT tended to accumulate in higher concentration in liver than in adipose tissue by the feeding for 12 months but tendency was reversed after the feeding for 18 months. The net weight of PCT accumulated in mouse liver increased continuously throughout the feeding period in the 100 ppm dietary level, while, it decreased significantly at the later period of feeding at 20 ppm. Based on the statistical analyses of the results obtained from all individual mice, it was found that PCT concentration in adipose tissue was correlated well with that in liver, kidney, skin and brain, respectively.
公益社団法人日本薬学会の論文
1982-02-28