二塩化ビフェニルおよび十塩化ビフェニルのラットにおける体内分布ならびに排泄

概要

論文の詳細を見る
After a single oral administration of p, p'-dichlorobiphenyl (Cl_2-BP) or decachlorobiphenyl (Cl_<10>-BP) to male rate the distribution of each chlorinated biphenyl in several organs and tissues of these rats and excretion of each compound into urine and feces were investigated. Only a part of Cl_2-BP and Cl_<10>-BP administered to rats was absorbed through the gastrointestinal tract, and a small amount of each compound was excreted into urine, but most of both compounds were excreted into feces. Both chlorinated biphenyls were very quickly distributed in all rat tissues, especially in hypodermic adipose tissue and skin, and later, both compounds were very slowly excreted into urine. The biological half lives of Cl_2-BP and Cl_<10>-BP in the rat tissues were found in the range of 5.5 hr in lung to 26.4 hr in hypodermic adipose, and in the range of 83 hr in the liver to 513 hr in hypodermic adipose tissue. It was indicated that Cl_<10>-BC was retained for a longer period than Cl_2-BP in the rat tissues and it was suggested that the metabolism and excretion of Cl_<10>-BP in rat were extremely slower than those of Cl_2-BP.
社団法人日本薬学会の論文
1976-08-31