家庭用品による接触皮膚炎の原因化学物質の追求(第6報) : 手術用ゴム手袋中の老化防止剤及び加硫促進剤

概要

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Antioxidants and accelerators in 24 brands of commercially available surgical rubber gloves were analyzed by the procedures proposed in the previous papers [Eisei Kagaku, 30,126 (1984) ; ibid, 32,197 (1986)]. Phenolic antioxidants and dithiocarbamate-type accelerators (DTCs) were present in almost all surgical rubber gloves. Two kinds of diphenylamine-type antioxidants were found in a brand. In addition, aniline was found in 4 brands, but its source is still unknown. Six brands of surgical gloves used in a hospital were patch tested to 78 volunteers, doctors and nurses working in the hospital. Then, multi-regression analysis was performed to estimate the degree of distribution of DTCs or amines to positive reaction incidence to the gloves. As the results, we could conclude that dimethylamine derivatives such as zinc dimethyldithiocarbamate and dimethylamine were the most important causative chemicals in contact dermatitis from surgical rubber gloves.
公益社団法人日本薬学会の論文
1988-08-30