家庭用品による接触皮膚炎の原因化学物質の追求(第1報)作業用ゴム手袋中のN-Isopropyl-N'-phenyl-p-phenylenediamineについて

概要

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A case of allergic contact dermatitis caused by heavy duty rubber gloves was reported. On patch testing with three kinds of gloves used by the patient and with various rubber additives, he reacted with only the rubber gloves and with N-isopropyl-N'-phenyl-p-phenylenediamine (IPPD). These reactions continued for two weeks. Chemical analysis clarified that the gloves contained IPPD and styrenated phenol (SP) at levels of 177 and 1600μg/g, respectively. The analytical procedure was as follows : 1) extraction by shaking with acetone : chloroform (1 : 1) mixture at room temperature ; 2) fractionation by silica gel column chromatography, by using hexane, ether : hexane mixture of various ether contents (5,10,50%) and ether as eluants ; 3) clean-up by silica gel thin-layer chromatography, by using chloroform : benzene (10 : 9) mixture as a developing solvent ; 4) qualitative and quantitative analysis by gas chromatography (GC) on 3% SE-30 column and GC-mass spectrometry. From the results mentioned above, we considered that IPPD should be a causative agent in this case. Since some phenolic compounds have been identified as sensitizers and SP is a kind of them, SP is also anticipated to be causative. The possibility could not be ruled out, because SP was not applied to patch testing.
公益社団法人日本薬学会の論文
1982-06-30