Syntheses, Immunosuppressive Activity, and Structure-Activity Relationships of Myriocin Analogs, 2-epi-Myriocin, 14-Deoxomyriocin, Z-14-Deoxomyriocin, and Nor-deoxomyriocins
スポンサーリンク
概要
- 論文の詳細を見る
Nine myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, were synthesized from 2-deoxy-D-glucose via common intermediates used in previous myriocin and Z-myriocin syntheses. Immunosuppressive activites of those myriocin analogs on mouse allogeneic mixed lymphocyte reaction were examined, and Z-14-deoxomyriocin was found to show the most potent activity among them. The structure-activity relationships are discussed.
- 公益社団法人日本薬学会の論文
- 1995-10-15
著者
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吉川 雅之
Kyoto Pharmaceutical Univ.
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村上 啓寿
Kyoto Pharmaceutical University
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矢木 信博
京都薬科大学生薬学教室
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村上 啓寿
阪大院薬:presto
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矢木 信博
Kyoto Pharmaceutical University
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奥野 安洋
Kyoto Pharmaceutical University
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Murakami Takayuki
Taiho Pharmaceutical Co. Ltd.
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横川 佳浩
Kyoto Pharmaceutical University
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横川 佳浩
大阪大学薬学部
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Yokokawa Y
Kyoto Pharmaceutical University
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