Syntheses, Immunosuppressive Activity, and Structure-Activity Relationships of Myriocin Analogs, 2-epi-Myriocin, 14-Deoxomyriocin, Z-14-Deoxomyriocin, and Nor-deoxomyriocins

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概要

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• Nine myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, were synthesized from 2-deoxy-D-glucose via common intermediates used in previous myriocin and Z-myriocin syntheses. Immunosuppressive activites of those myriocin analogs on mouse allogeneic mixed lymphocyte reaction were examined, and Z-14-deoxomyriocin was found to show the most potent activity among them. The structure-activity relationships are discussed.

• 公益社団法人日本薬学会の論文
• 1995-10-15

著者

• 吉川 雅之

  Kyoto Pharmaceutical Univ.

• 村上 啓寿

  Kyoto Pharmaceutical University

• 矢木 信博

  京都薬科大学生薬学教室

• 村上 啓寿

  阪大院薬:presto

• 矢木 信博

  Kyoto Pharmaceutical University

• 奥野 安洋

  Kyoto Pharmaceutical University

• Murakami Takayuki

  Taiho Pharmaceutical Co. Ltd.

• 横川 佳浩

  Kyoto Pharmaceutical University

• 横川 佳浩

  大阪大学薬学部

• Yokokawa Y

  Kyoto Pharmaceutical University

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