TOTAL SYNTHESIS OF A NOVEL IMMUNOSUPPRESSANT, MYRIOCIN (THERMOZYMOCIDIN, ISP-I), AND Z-MYRIOCIN
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概要
- 論文の詳細を見る
Myriocin (thermozymocidin, ISP-I), which was known to exhibit several interesting biological properties such as potent immunosuppressive and antifungal activities, and a new analog Z-myriocin were synthesized from 2-deoxy-D-glucose. This synthetic pathway comprises a stereoselective formation of the chiral α, α-disubstituted amino acid structure in myriocin and Z-myriocin from the isopropylidene six-menbered ketone by using a modified Darzen reaction as its key step.
- 公益社団法人日本薬学会の論文
- 1994-04-15
著者
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吉川 雅之
Kyoto Pharmaceutical Univ.
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村上 啓寿
Kyoto Pharmaceutical University
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奥野 安洋
Kyoto Pharmaceutical University
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横川 佳浩
Kyoto Pharmaceutical University
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横川 佳浩
大阪大学薬学部
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Yokokawa Y
Kyoto Pharmaceutical University
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