SYNTHESES OF NEW IMMUNOSUPPRESSIVE MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS : THEIR STRUCTURE-ACTIVITY RELATIONSHIPS
スポンサーリンク
概要
- 論文の詳細を見る
Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, were synthesized from 2-deoxy-D-glucose via common intermediates in previous myriocin and Z-myriocin syntheses. The immunosuppressive activities of new myriocin analogs and Z-myriocin on mouse allogeneic mixed lymphocyte reaction were examined, and, by comparing with those of myriocin and 14-deoxomyriocin, some structure-activity relationships have been found.
- 公益社団法人日本薬学会の論文
- 1994-12-15
著者
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吉川 雅之
Kyoto Pharmaceutical Univ.
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村上 啓寿
Kyoto Pharmaceutical University
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矢木 信博
京都薬科大学生薬学教室
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矢木 信博
Kyoto Pharmaceutical University
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奥野 安洋
Kyoto Pharmaceutical University
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横川 佳浩
Kyoto Pharmaceutical University
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横川 佳浩
大阪大学薬学部
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Yokokawa Y
Kyoto Pharmaceutical University
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