SYNTHESES OF PSEUDO-α-D-GLUCOPYRANOSE, PSEUDO-β-D-GLUCOPYRANOSE, AND VALIDAMINE FROM D-GLUCURONOLACTONE
スポンサーリンク
概要
- 論文の詳細を見る
Using a stereoselective nitromethane addition and a reductive elimination of an ethoxyethoxyl moiety with NaBH_4 as key steps, two optically active pseudo-sugars, pseudo-α-D-glucopyranose and pseudo-β-D-glucopyranose, were synthesized from D-glucuronolactone in favorable overall yield. Furthermore, a biologically active pseudo-aminosugar, validamine, was synthesized via a substitution reaction for an acetoxyl group at the β-position of the nitro group in the nitrocyclitol derivative which was prepared from a synthetic intermediate of pseudo-D-glucopyranose.
- 公益社団法人日本薬学会の論文
- 1993-06-15
著者
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吉川 雅之
Kyoto Pharmaceutical Univ.
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村上 啓寿
Kyoto Pharmaceutical University
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北川 勲
Faculty Of Pharmaceutical Sciences Osaka University
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井上 泰尚
Kyoto Pharmaceutical University
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黒田 泰行
Faculty of Pharmaceutical Sciences, Osaka University
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黒田 泰行
Faculty Of Pharmaceutical Sciences Osaka University
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