Diamines Prevent Thermal Aggregation and Inactivation of Lysozyme(BIOCHEMICAL ENGINEERING)

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概要

• 論文の詳細を見る

• Protein aggregation is a major obstacle in both biological applications and biomedical fields involving proteins. In this study, we investigated the essential structure of small additives that function as chemical chaperones. Aggregation-suppressing competent additives were 1, 3-diaminopropane, 1, 4-diaminobutane, and 1, 5-diaminopentane, which suppressed aggregation in the given order; whereas no diols or monoamines prevented the thermal aggregation and the inactivation of lysozyme. The heat-inactivation rate of lysozyme with 1, 3-diaminopropane was almost identical to that of lysozyme with spermine and arginine ethylester, which are the most prominent additives reported yet.

• 社団法人日本生物工学会の論文
• 2005-11-25

著者

• Takagi Masahiro

  School Of Materials Science Japan Advanced Institute Of Science And Technology

• Takagi M

  School Of Materials Science Japan Advanced Institute Of Science And Technology

• Takagi Mutsumi

  International Center For Biotechnology Osaka University:(present Address)division Of Biotechnology A

• Takagi M

  Japan Advanced Inst. Of Sci. And Technol. Ishikawa Jpn

• NISHIKORI SHINGO

  School of Materials Science, Japan Advanced Institute of Science and Technology

• KUDOU Motonori

  School of Materials Science, Japan Advanced Institute of Science and Technology

• Takagi M

  Nagasaki Univ. Nagasaki Jpn

• SHIRAKI Kentaro

  Institute for Applied Physics, University of Tsukuba

• Shiraki K

  Institute Of Applied Physics University Of Tsukuba

• Shiraki Kentaro

  Institute For Applied Physics University Of Tsukuba

• Okanojo Masahiro

  School of Materials Science, Japan Advanced Institute of Science and Technology

• Takagi Mutsumi

  School Of Materials Science Japan Advanced Institute Of Science And Technology

• Kudou Motonori

  School Of Materials Science Japan Advanced Institute Of Science And Technology

• Kudou Motonori

  School Of Material Science Japan Advanced Institute Of Science And Technology

• Takagi Masahiro

  School Of Material Science Japan Advanced Institute Of Science And Technology

• Okanojo Masahiro

  School Of Materials Science Japan Advanced Institute Of Science And Technology

• Nishikori Shingo

  Division Of Molecular Cell Biology Institute Of Molecular Embryology And Genetics Kumamoto Universit

• Takagi Masahiro

  Graduate School Of Biological Sciences Nara Institute Of Science And Technology (naist)

• Nishikori Shingo

  School of Materials Science, Japan Advanced Institute for Science and Technology

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