Thiamin Tetrahydrofurfuryl Disulfideまたはチアミン含有内服用液剤を健康成人男子が服用した時のビタミンB_1の薬物動態

概要

論文の詳細を見る
Liquid preparations containing 5 mg or 10 mg of thiamin tetrahydrofurfuryl disulfide hydrochloride (TTFD-HCl) and 2 kinds of liquid preparations containing 10 mg of thiamin nitrate were given to healthy male subjects, and the bioavailability of vitamin B_1 after administration of each preparation was investigated. It was found that the C_<max>, AUC and 24-hour urinary excretion after oral administration of 10 mg of TTFD in liquid preparation was about twice those of 5 mg of TTFD in liquid preparations. No difference was observed between T_<max> after the administration of 10 mg and 5 mg of TTFD in liquid preparations. The C_<max>, AUC and 24-hour urinary excretion after the administration of 10 mg of thiamin nitrate in liquid preparations were lower than those of 5 mg of TTFD in liquid preparations.
日本ビタミン学会の論文
1992-09-25