実験的カドミウム中毒に関する研究 : (2) 低たんぱく質, カルシウム欠乏がラットのカドミウム中毒に及ぼす影響

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Male rats of Wistar strain were separated into eight groups and various synthetic diets were given to each group. Group I was fed a high protein and calcium sufficient diet, Group II a low protein and calcium sufficient diet, Group III a high protein, calcium sufficient and cadmium added diet, Group IV a low protein, calcium sufficient and cadmium added diet, Group V a high protein and calcium deficient diet, Group VI a low protein and calcium deficient diet, Group VII a high protein, calcium deficient and cadmium added diet. A low protein, calcium deficient and cadmium added diet was given to the VIII group.After 4 weeks of these dietary regimens the rats were sacrificed and examined roentgenographically. Various tissues were removed and utilized for determination of cadmium, calcium, magnesium and zinc.The most remarkable X-ray finding was the abnormal curvature of the spinal column. Rats of I to VII groups had normal cervicodorsal lordosis and dorsolumbar kyphosis. In contrast, cervicodorsal lordosis and dorsolumbar kyphosis as well as scoliosis increased markedly in group VIII.Cadmium levels increased and magnesium and zinc levels decreased in bones of cadmium administered group III, IV, VII and VIII. Calcium levels in red muscle (soleus) and white muscle (gastrocnemius) were significantly elevated in group VIII.