実験的カドミウム中毒に関する研究 : (3) In Vivo, In VitroにおいてカドミウムがラットのNa-K-Mg-dependent ATPase, Mg-dependent ATPaseおよびTransketolaseにおよぼす影響

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A study of the in vitro and in vivo effects of cadmium on rat liver enzymes showed:1) The addition of cadmium (10-4 M) to liver homogenate resulted in a marked inhibition of Na-K-Mg-dependent ATPase, but had no effect on Mg-dependent ATPase or transketolase.2) When 2.5 or 5 μg of cadmium was administered to rats twice a week for three months, their liver Na-K-Mg-dependent ATPase activity decreased significantly, but there was no significant change in Mg-dependent ATPase or transketolase activity.3) Separation of the livers of cadmium treated rats into subcellular fractions (i.e. nuclei, mitochondria, microsomes and supernatant) showed that about 80% of the cadmium was in the acid soluble fraction of the supernatant.
日本衛生学会の論文