総合ビタミン剤を長期服用した場合の健康成人のビタミンB_1及びB_2の血中濃度・尿中排泄

概要

論文の詳細を見る
To clarify the effect of the long-term administration of a commercial multivitamin tablet containing 5 mg of thiamin tetrahydrofurfuryl disulfide (TTFD), 3.5 mg of riboflavin, and other vitamins, two or four tablets daily were administered orally to healthy subjects for 44 weeks. The blood thiamin concentrations increased gradually during administration and showed a maximum concentration at 44 weeks. The blood thiamin concentrations in the 4 tablets/day group were higher than those in the 2 tablets/day group at all times. Dose-dependence of the blood thiamin concentrations in the three groups including placebo group during the experimental period was shown to be significant by linear regression analysis. The urinary thiamin excretion in the 2 and 4 tablets/day groups was higher than in the placebo group at all times. The blood riboflavin concentrations also increased steadily during the administration period, but the increase was less than that noted for the thiamin concentration. Urinary excretion of riboflavin was higher in the multivitamin groups than in the placebo group. Therefore, it is concluded that the daily oral administration of TTFD and riboflavin in a multivitamin preparation produces a significant increase of thiamin and riboflavin levels.
日本ビタミン学会の論文
1991-11-25