総合ビタミン剤長期服用による健康成人の全血総ビタミンB_6,ニコチン酸濃度及び尿中B_6,ニコチン酸代謝物質排泄量の変動

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In order to study the effect of a long-term (44 weeks) oral administration of a multivitamin preparation on vitamin B_6 and nicotinic acid status in normal subjects (7 healthy male adults aged in 21-24 years for each group), the total B_6 and nicotinic acid levels in whole blood were determined by HPLC methods, as well as urinary excretions of their metabolites. In the samples collected at 24 hours after taking of the medicine, the whole blood concentration of total B_6 in double dosage group (hereinafter group I), taking 18 mg of PN-HCl (pyridoxine hydrochloride) and 150 mg of NiA-NH_2 (nicotinamide) daily, was elevated to 6 times of the baseline at 4th week, and reached a plateau and kept on a level until 44th week. After cessation of the medicine the total B_6 level descended to the baseline after two weeks. The total B_6 level in the group of ordinary dosage (group II), taking 9 mg of PN-HCl and 75 mg of NiA-NH_2, was elevated to 3 times of the baseline at 4th week, and at the same time reached a plateau, and after two weeks from the cessation returned to the baseline. No significant change was found in placebo group (group III) throughout all experimental period. No significant elevation was found in all groups on blood total nicotinic acid level at 24 hours after taking the medicine. The urinary excreted PIC (4-pyridoxic acid) in group I was 11.35 ± 2.82 mg/day at 4th week, and subsequently increased slightly into a level of 15.81 ± 2.45 mg/day at 44th week, and after one week from the cessation returned within normal range. In group II the urinary excreted PIC was 5.38 ± 1.51 mg/day at 4th week, and 6.79 ± 1.59 mg/day at 44th week, and returned within normal range after one week from the cessation. No significant difference was found between group I and II in the mean of 24 hours urinary PIC excretion ratios (as PN (pyridoxine)). In the group I the urinary excreted MNA (N'-methylnicotinamide) was 34.2 ± 1.9 mg/day at 4th week, and 34.5 ± 7.7 mg/day at 44th week, and after one week the cessation returned on the baseline. In group II the urinary excreted MNA was 20.4 ± 7.2 mg/day at 4th week, and 19.7 ± 3.0 mg/day at 44th week, and after one week from the cessation returned to the baseline. No significant difference was found between I and II group in the urinary excretion ratios of MNA (as NiA-NH_2). The bioavailabilities of B_6 and nicotinic acid contained an ordinary dosage of multivitamin preparation were confirmed by the dose responsive change of blood B_6 level, urinary PIC and MNA excretion.
日本ビタミン学会の論文
1991-11-25

総合ビタミン剤長期服用による健康成人の全血総ビタミンB_6,ニコチン酸濃度及び尿中B_6,ニコチン酸代謝物質排泄量の変動

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