ビタミン剤投与時における血中及び尿中ビタミンB_6,ニコチン酸の変動

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Effects of oral administration of three kinds of B-vitamin preparation, including 1.65mg of pyridoxine (PN), and multivitamin preparation, including 7.41mg of PN and 75mg of nicotinamide (NiA-NH_2), were studied in healthy young male adults (n=5) on blood total vitamin B_6 and nicotinic acid (NiA) levels, as well as urinary excretion. (1) When a 1.65mg of PN was once orally administered after breakfast, the elevation of blood vitamin B_6 levels were 3.1 times of baseline levels after one hour, and then 22.9% of PN given were excreted as a form of 4-pyridoxic acid (PIC) in 24 hours. When 7.41mg of PN were given, the elevation of blood vitamin B_6 levels were 8.5 times of baseline levels and the 27.4% of administered dose was excreted. (2) When a 7.4mg of PN was daily administered during 7 days, the daily elevation of blood vitamin B_6 levels was calculated by the areas under the blood vitamin B_6 curve for 24 hours after administration. The areas after the 7th day's administration was 2.2 times higher than those after the 1st day's administration. Urinary excretion of PIC and its metabolites increased immediately after administration and then reached a maximum level in the 2nd day, the levels being in plateau thereafter. (3) When 75mg of NiA-NH_2 were daily administered during the same period, the areas surrounded with blood total NiA curve and the baseline at the 7th days' administration was 24.6% lower than that of the 1st day. Contrarily, urinary MNA excretion increased from 18.7% of the administered dose at the 1st day to 23.6% at the 7th day. This indicates that the metabolic turnover of NiA was accelerated by repeated administration of NiA-NH_2.
日本ビタミン学会の論文
1989-06-25

ビタミン剤投与時における血中及び尿中ビタミンB_6,ニコチン酸の変動

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