Clinical significance of the assay of 7S and type IV collagen in the sera of patients with various liver diseases. Comparison with P-III-P and laminin P1 concentrations.:Comparison wth P-III-P and laminin P1 concentrations

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7S and type IV collagen concentrations in the sera of 293 patients wth various liver diseases were assayed.<BR>Normal values obtained from 20 healthy male adults were 3.48±1.10ng/ml for 7S and 99.3±24.8ng/ml for type IV collagen. Serum levels exceeding 5ng/ml for 7S and 140ng/ml for type IV collagen were defined as positive. Rate of positivity was higher in hepatocellular carcinoma (HCC) (86.1%), metastatic liver cancer (Meta-Ca) (73.3%), liver cirrhosis (LC) (76.9% for 7S and 66.2% for type IV) and alcoholic liver diseases (ALD) (41.2% for 7S, 55.9% for type IV). The assayed values were high in the order of Meta-Ca, HCC, LC and ALD. Between HCC with LC and without LC, assayed values were not significantly different.<BR>Coefficients of correlation between 7S and type IV in each disease groups were 0.55 to 0.83. In HCC, 7S and type IV showed high correlationship with laminin P1 or P-III-P.
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