<Originals>Establishment and characteristics of rat with precocious and severe hypertension (M-SHRSP)

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概要

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• Through brother-sister breeding of selected stroke-prone SHR (SHRSP) evidencing high blood pressure at an early stage of development for 20 generations, an inbred strain of malignant or precocious SHRSP (M-SHRSP), showing blood pressures as high as 250 mmHg or more before 14 weeks of age, was established by administering hydralazine hydrochloride during mating and lactation. Compared to SHRSP, M-SHRSP evidences more rapid and severe increases in blood pressure. The incidence of cerebrovascular lesions is over 95%, somewhat higher than that of SHRSP. But there is a remarkable increase in the incidence of multiple small or petechial hemorrhages at the base of the brain. In later generations, the life span for male M-SHRSP has come to be about 90 days, and for the female, about 120 days. This is about 1/2 that of SHRSP and around 1/4 that of Wistar-Kyoto rats (WKY). Blood pressure of the hybrid (WT) obtained by crossbreeding M-SHRSP and WKY were intermediate to those of the parents. Those of the offspring obtained by backcrossing WT with WKY for 3 generations were intermediate to those of the parents and by the third generation had gradually decreased to nearly normotensive values of less than 150 mmHg. Those of the offspring obtained by backcrossing WT with M-SHRSP for 4 generations were also intermediate to those of the parents and by the fourth generation had gradually returned to the levels found in M-SHRSP. M-SHRSP hypertension is not inherited in accordance with the simple Mendelian laws of inheritance. Strains of rats with the blood pressure of various levels between those of M-SHRSP and WKY (i.e., between 135 and 250 mmHg) can be readily produced by suitable crossbreeding of M-SHRSP and WKY.

• 近畿大学の論文

著者

• Ohta Y

  Hiroshima Prefectural Food Technology Research Center

• Ohta Y

  First Department Of Pathology Kinki University School Of Medicine

• Ohta Yoshio

  Hiroshima Prefectural Food Technology Research Center

• Okamoto K

  First Department Of Pathology Kinki University School Of Medicine

• Okamoto Kozo

  First Department Of Pathology Kinki University School Of Medicine

• Okamoto Kozo

  Research Institute Of Food Science School Of Medicine Kinki University

• Yamamoto Kentaro

  First Department Of Internal Medicine Kinki University

• Ohta Yoshio

  First Department Of Pathology Kinki University School Of Medicine

• MORITA Nobuko

  First Department of Pathology, Kinki University School of Medicine

• YAMAMOTO Kazuo

  First Department of Pathology, Kinki University School of Medicine

• Morita N

  Faculty Of Home Economics Kobe Women's University

• Morita Nobuko

  First Department Of Pathology Kinki University School Of Medicine

• Yamamoto K

  First Department Of Internal Medicine Kinki University

• Okamoto Kozo

  First Department Of Pathology Kinki University

• Yamamoto Kentarou

  The First Department Of Internal Medicine Kinki University

• YAMAMOTO Kazuo

  First Department of Internal Medicine, Kinki University

• OKAMOTO Kozo

  First Department of Pathology , Kinki University School of Medicine

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