<Originals>A study on intracranial hypertension and its pathogenesis in SHR
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Using male M-SHRSP, SHRSP, SHR B_2 and SHR C, with WKY as the control, the author measured cerebrospinal fluid pressure by the cisternal puncture method. He also measured brain parenchyma water content and brain volume and investigated their relationships to blood pressure levels. When M-SHRSP, SHRSP or SHR B_2 blood pressures reached 210 mmHg, their cerebrospinal fluid pressures also begin to rise ; the correlation being positive. However, no cerebrospinal fluid pressure increases were found for SHR C with blood pressures under 210 mmHg or for normotensive rats. It is also very common to find cerebral blood vessel hyperpermeability and increased incidence of cerebrovascular lesions in rats with blood pressures of 210 mmHg or more. Positive correlations were found between blood pressure and brain parenchyma water content, between brain parenchyma water content and brain volume as well as between the former and cerebrospinal fluid pressure and between brain volume and cerebrospinal fluid pressure. These results appear to suggest that severe arterial hypertension increases cerebral blood vessel hyperpermeability and brain edema. As a result, the acute increase in brain volume within the fixed capacity of the intracranial space gives rise to intracranial hypertension, which in turn can be considered to be a cause of severe cerebellar herniation and accompanying hydrocephalus. This development of severe cerebellar herniation and hydrocephalus is thought to give rise to even higher intracranial pressure levels. The results of electrocardiogram, intercostal electromyogram and patho-histological examination clearly showed that intracranial hypertension also disturbed cardiac and respiratory functions, meaning it might be one of the causes for death among M-SHRSP, SHRSP and SHR B_2.
- 近畿大学の論文
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