<Originals>Studies on plasma aldosterone in M-SHRSP and other SHR strains (2) : changes in plasma aldosterone and other alterations in M-SHRSP given several drugs

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概要

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• Using 10-week-old male M-SHRSP, a strain of rat with severe precocious hypertension, zona glomerulosa hypertrophy and increases in plasma aldosterone concentrations (PAC) were investigated following administration of metopirone, spironolactone, captopril, or guanethidine sulfate. Results were : (1) After administering metopirone, spironolactone or captopril for 2 weeks, PAC values decreased significantly while the administration of guanethidine prevented an increase in PAC values. (2) Blood pressures decreased significantly only in the group given captopril. (3) Captopril reduced plasma renin concentrations but metopirone increased these values. (4) The adrenal weight to total body weight ratio decreased in the group given captopril, but increased significantly in the groups administered metopirone or guanethidine. (5) Adrenal zona glomerulosa hypertrophy (thickening) was seen in the group administered metopirone, but for the other groups there was a tendency for the adrenal zona glomerulosa to be thinner than those of non-treated controls. This thinning was particularly significant in the captopril group, with values nearly equalling those of normotensive Wistar-Kyoto rats. (6) Administering captopril or spironolactone for two weeks remarkably prolonged the life spans. Overall, these results suggest that deterioration of the renin-angiotensin system increases hypertension in M-SHRSP, but that aldosterone, itself, is not an important factor.

• 近畿大学の論文

著者

• Ohta Y

  Hiroshima Prefectural Food Technology Research Center

• Ohta Y

  First Department Of Pathology Kinki University School Of Medicine

• Ohta Yoshio

  Hiroshima Prefectural Food Technology Research Center

• Okamoto K

  First Department Of Pathology Kinki University School Of Medicine

• Okamoto Kozo

  First Department Of Pathology Kinki University School Of Medicine

• Okamoto Kozo

  Research Institute Of Food Science School Of Medicine Kinki University

• Ohta Yoshio

  First Department Of Pathology Kinki University School Of Medicine

• MORITA Nobuko

  Faculty of Home Economics, Kobe Women's University

• SHIOKAWA Hiroki

  First Department of Pathology, Kinki University School of Medicine

• Morita N

  Faculty Of Home Economics Kobe Women's University

• Shiokawa Hiroki

  First Department Of Pathology Kinki University School Of Medicine

• Okamoto Kozo

  First Department Of Pathology Kinki University

• MORITA Nobuko

  Faculty of Home Economics, Kobe Women's University

• OKAMOTO Kozo

  First Department of Pathology , Kinki University School of Medicine

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