Production of Novel Antioxidative Prenyl Naphthalen-ols by Combinational Bioconversion with Dioxygenase PhnA1A2A3A4 and Prenyltransferase NphB or SCO7190

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概要

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• We performed combinational bioconversion of substituted naphthalenes with PhnA1A2A3A4 (an aromatic dihydroxylating dioxygenase from marine bacterium Cycloclasticus sp. strain A5) and prenyltransferase NphB (geranyltransferase from Streptomyces sp. strain CL190) or SCO7190 (dimethylallyltransferase from Streptomyces coelicolor A3(2)) to produce prenyl naphthalen-ols. Using 2-methylnaphthalene, 1-methoxynaphthalene, and 1-ethoxynaphthalene as the starting substrates, 10 novel prenyl naphthalen-ols were produced by combinational bioconversion. These novel prenyl naphthalen-ols each showed potent antioxidative activity against a rat brain homogenate model. 2-(2,3-Dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one (2′,3′-dihydroxychrysin) generated with another aromatic dihydroxylating dioxygenase and subsequent dehydrogenase was also geranylated at the C-5′-carbon by the action of NphB.

• 2011-03-23

著者

• Nishiyama Makoto

  Biotechnology Research Center The University Of Tokyo

• Shindo Kazutoshi

  Department Of Food And Nutrition Japan Women's University

• Tanaka Ayumi

  Department Of Materials Science And Engineering Faculty Of Engineering And Resource Science Akita Un

• TACHIBANA Ayako

  Department of Food and Nutrition, Japan Women’s University

• TOBA Shizuka

  Department of Food and Nutrition, Japan Women’s University

• YUKI Emi

  Department of Food and Nutrition, Japan Women’s University

• OZAKI Taro

  Biotechnology Research Center, The University of Tokyo

• KUMANO Takuto

  Biotechnology Research Center, The University of Tokyo

• MISAWA Norihiko

  Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University

• Kumano Takuto

  Biotechnology Research Center The University Of Tokyo

• Kuzuyama T

  Univ. Tokyo Tokyo

• Kuzuyama Tomohisa

  Biotechnology Research Center The University Of Tokyo

• Kuzuyama Tomohisa

  Biotech. Research Center Tokyo Univ.

• Tanaka Ayumi

  Department Of Food And Nutrition Japan Women's University

• Yuki Emi

  Department Of Food And Nutrition Japan Women's University

• Misawa Norihiko

  Research Institute For Bioresources And Biotechnology Ishikawa Prefectural University

• Toba Shizuka

  Department Of Food And Nutrition Japan Women's University

• Ozaki Taro

  Biotechnology Research Center The University Of Tokyo

• Tanaka Ayumi

  Department Of Botany Faculty Of Science Kyoto University

• Tachibana Ayako

  Department Of Food And Nutrition Japan Women's University

• Nishiyama Makoto

  Atopy (Allergy) Research Center, Juntendo University School of Medicine

• MISAWA Norihiko

  Reseach Institute for Bioresources and Biotechnology, Ishikawa Prefectural University

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