Metabolism of 4-Amino-3-hydroxybenzoic Acid by Bordetella sp. Strain 10d : A Different Modified Meta-Cleavage Pathway for 2-Aminophenols
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概要
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Bordetella sp. strain 10d metabolizes 4-amino-3-hydroxybenzoic acid via 2-hydroxymuconic 6-semialdehyde. Cell extracts from 4-amino-3-hydroxybenzoate-grown cells showed high NAD+-dependent 2-hydroxymuconic 6-semialdehyde dehydrogenase, 4-oxalocrotonate tautomerase, 4-oxalocrotonate decarboxylase, and 2-oxopent-4-enoate hydratase activities, but no 2-hydroxymuconic 6-semialdehyde hydrolase activity. These enzymes involved in 4-amino-3-hydroxybenzoate metabolism were purified and characterized. When 2-hydroxymuconic 6-semialdehyde was used as substrate in a reaction mixture containing NAD+ and cell extracts from 4-amino-3-hydroxybenzoate-grown cells, 4-oxalocrotonic acid, 2-oxopent-4-enoic acid, and 4-hydroxy-2-oxovaleric acid were identified as intermediates, and pyruvic acid was identified as the final product. A complete pathway for the metabolism of 4-amino-3-hydroxybenzoic acid in strain 10d is proposed. Strain 10d metabolized 2-hydroxymuconic 6-semialdehyde derived from 4-amino-3-hydroxybenzoic acid via a dehydrogenative route, not via a hydrolytic route. This proposed metabolic pathway differs considerably from the modified meta-cleavage pathway of 2-aminophenol and those previously reported for methyl- and chloro-derivatives.
- 社団法人 日本農芸化学会の論文
- 2006-11-23
著者
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Aoki K
Department Of Applied Biological Chemistry Graduate School Of Agricultural Science Kobe University
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Takenaka Shinji
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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MURAKAMI Shuichiro
Department of Bioscience, Biotechnology, and Agrochemistry, Faculty of Agriculture, Meiji University
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AOKI Kenji
Department of Nutritional Management, Faculty of Nutritional Science, Sagami Women’s University
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Murakami S
Kikkoman Corp. Chiba Pref. Jpn
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ORII Chika
Division of Science of Biological Resources, Graduate School of Science and Technology, Kobe Univers
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Orii Chika
Division Of Science Of Biological Resources Graduate School Of Science And Technology Kobe Universit
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Murakami Shuichiro
Dep. Of Bioscience Biotechnology And Agrochemistry Fac. Of Agriculture Meiji Univ.
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Aoki Kenji
Department Of Nutritional Management Faculty Of Nutritional Science Sagami Women's University
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Takenaka Shinji
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University
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Aoki K
Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University
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Murakami Shuichiro
Department Of Bioscience Biotechnology And Agrochemistry Faculty Of Agriculture Meiji University
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Aoki Kenji
Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University
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MURAKAMI Shuichiro
Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University
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