Stereochemistry of hydroxymethylations of N-salicylideneglycyl dipeptide copper(II) complexes. A kinetically and also thermodynamically controlled reaction.
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概要
- 論文の詳細を見る
(<I>N</I>-Salicylideneglycyl-L-valinato)copper(II) or (<I>N</I>-salicylideneglycyl-L-isoleucinato)copper(II) was treated with formaldehyde in an aqueous solution under relatively mild conditions. It was found that the resulting seryl residue was D-configuration in the early stage of the reaction. However, the configuration was inverted from D- to L-form after prolonged reaction. The epimerization reactions of authentic (<I>N</I>-salicylideneglycyl-D- or L-seryl-L-isoleucinato)copper(II) were carried out under similar conditions. These results indicate that the reaction as a whole is controlled kinetically as well as thermodynamically.
- 公益社団法人 日本化学会の論文
著者
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Suzuki Shinnichiro
Department Of Chemistry Graduate School Of Science Osaka University
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Harada Kaoru
Department of Chemistry Faculty of Science Osaka University
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Narita Hideyuki
Department of Chemistry, University of Tsukuba
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