THE RELATION BETWEEN PURINE METABOLISM AND FLAVINOGENESIS IN EREMOTHECIUM ASHBYII : THE IDENTIFICATION OF S-ADENOSYLMETHIONINE AND S-ADENOSYLHOMOCYSTEINE ACCUMULATED IN NON-GROWING CELLS OF E. ASHBYII

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When adenine was added to the non-growing cell medium of Eremothecium ashbyii, riboflavin production of the mold was increasingly inhibited with increasing concentration of adenine. Under these condi-tions, a cationic compound was accumulated in the mycelia. The com-pound was isolated from the mycelia and highly purified. The purified compound was proved to be S-adenosylhomocysteine through IR analysis. In the control experiment, or in the addition of other purines which stimu-lated riboflavin production of the mold, another cationic compound was accumulated in the non-growing cells. The compound was largely accumulated in the presence of both adenine and methionine, isolated from the mycelia and purified. The purified compound was concluded to be S-adenosylmethionine through IR and NMR analyses. The signifi-cance of these compounds on the riboflavin biosynthetic pathway was argued under “DISCUSSION.”
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